通腑化痰活血法对大鼠脑梗塞后血液流变学的影响  

Effeet of the Therapy for Catharsis and Resolving Phlegm with PromotingBlood Flow on the Abnormal Blood Rheology at the Cerebral Embolism in Rats

作　　者：李威[1] 邹明辉[1] 李秋风[1] 苗利军[1] 杨宁辉[1] 

机构地区：[1]河南省中医药研究院中药研究所

出　　处：《中药药理与临床》1996年第3期3-6,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局青年基金

摘　　要：用兔脑凝血活酶粉－高分子葡聚糖给大鼠颈内动脉注射造成脑栓塞动物模型，观察了通腑化痰活血复方对实验性脑栓塞后２小时、３天、９天的血液流变学异常的纠正作用。结果表明，该方可降低实验性脑栓塞大鼠的全血粘度、血浆粘度和血球压积，增加红细胞变形能力，降低血小板聚集率，增加血小板５分钟解聚率，并可降低血浆　－ＴＧ含量，提高血浆ｃＡＭＰ含量。he cerebral embolism was established by injecting the solution of thromboplastin powed of rabbit brain and 10%dextran into the internal carotid artery if in rats. The effects of the therapy for catharsis and resolving phlegm with pro-moting blood flow (TCRP) on the blood rheology, platelet agglutination, -TG and cAMP content in plasma were ob-served at 2h, 3th day and 9th day after operations. The results showed that the TCRP could decrease the blood wiscosi-ty, packed cell volume, platelet agglutination and the -TG content of plasma, prevent the reduction of erythrodegener-ative and increase the cAMP content of plasma after the cerebral embolism in rats.

关 键 词：大鼠 通腑化痰 脑栓塞 血浆 活血法 实验性 脑梗塞 降低 解聚 高分子 

分 类 号：R743[医药卫生—神经病学与精神病学] R277[医药卫生—临床医学]