盐藻β-胡萝卜素预防实验性动脉粥样硬化形成的形态学观察  

MORPHOLOGICAL EVALUATION OF BETA-CAROTENE IN THE PREVENTION OF EXPERIMENTAL ATHEROSCLEROSIS IN QUAILS

作　　者：王春波[1] 蓝孝贞[1] 白玲[1] 张仁亮[1] 张鲁平[1] 周绪祥[1] 张敏[1] 王玉贞[1] 刘建国[2] 张京浦[2] 

机构地区：[1]青岛大学医学院,青岛266021 [2]中国科学院海洋研究所,青岛266071

出　　处：《中国海洋药物》1998年第2期6-10,共5页Chinese Journal of Marine Drugs

基　　金：国家科委"八五"攻关课题(85-07-08)

摘　　要：以鹌鹑动脉粥样硬化(AS)为模型,对从盐泽杜氏藻中提取的以顺式结构为主的β-胡萝卜素(β-C)预防实验性AS进行病理形态学观察,发现Ⅱ组(高饲对照组)动脉病变重,泡沫细胞约10～20层,平滑肌细胞增生,斑块发生率为91.67％。β-C组动脉病变轻,泡沫细胞仅约2～4层,斑块发生率明显少于Ⅱ组(P<0.05),且存在剂量依赖关系。结果表明,β-C能有效地抑制AS斑块的形成和发展。Beta-carotene(B-C) was isolated from Dunaliella salina and mainly composed of cis-isomer beta-carotene. A total of 81 experimental atherosclerotic quails were surveyed with morphological methods- It was found that the lessions in hypercholesterol group were severe with the incidence of atherogenic plaque being 91. 67%,and were mild in B-C groups with the incidence 88- 90% ,75% ,66. 7% , respectively. Significant difference was observed a- mong the groups (P<0. 05). Histological examinations showed that there were 10--20 layers of foam cells in hypercholesterol group,and 2-4 layers in B-C groups,which suggested that the proliferation of smooth muscle cells of B-C groupswas much less than that of control group. The results indicated that B-C could significantly inhibit atherosclerosis.

关 键 词：实验性动脉粥样硬化 斑块 泡沫细胞 预防 发生率 形态学观察 Β-胡萝卜素 病变 盐藻 剂量 

分 类 号：R543.5[医药卫生—心血管疾病] R541[医药卫生—内科学]