前列腺素在门脉高压性胃病大鼠胃粘膜灌注中的作用  

Effects of prostaglandin on gastric mucosal perfusion in rats with portal hypertensive gastropathy

作　　者：乐桥良[1] 张捷[1] 张贤康[2] 

机构地区：[1]福州总医院消化内科 [2]第二军医大学长征医院

出　　处：《福州总医院学报》2001年第3期153-155,共3页Journal of Fuzhou General Hospital

摘　　要：目的:探讨前列腺素(prostaplandin)在门脉高压性胃病(portal hypertensive gastropathy,PHG)大鼠胃粘膜灌注中的作用。方法:部分结扎大鼠门脉主干2wk后,采用中性红清除率法测定大鼠胃粘膜血流量(gastric mucosal blood flow,GMBF),同时观察了门静脉压力(PVP)、平均动脉压(MAP)和心率的变化。结果:PHG组大鼠MAP和心率与假手术组比无明显差异(P>0.05)。PHG组大鼠GMBF和PVP显著高于假手术组(P<0.01)。前列腺素环氧合酶抑制剂吲哚美辛(indomethacin)能明显降低PHG组大鼠GMBF(P<0.05),而对假手术组GMBF无明显影响。结论:前列腺素在调节PHG大鼠的GMBF起重要作用。Objective: To observe the Effects of prostaglandin on gastric mucosal perfusion in rats with portal hypertensive gastropathy (PHG) .Methods: Tow weeks after partial portal vein ligation, gastric mucosal blood flow (GMBF) was measured by the neutral red clearance, the changes of PVP, MAP and heart rate were observed, Results: There were no significant differences of MAP and heart rate both PHG and sham operated rats (P>0.05) . GMBF and PVP were significantly higher in rats with PHG than in sham operated rats (P<0.01) . The inhibition of prostaglandin synthesis with indomethacin significantly decreased GMBF in rats with PHG (P<0.05), but had no effect in sham operated rats (P>0.05) . Conclusion: Prostaglandin plays an important role in the regulation of GMBF in rats with PHG.

关 键 词：大鼠 前列腺素 PHG 门脉高压性胃病 胃粘膜血流量 手术 灌注 心率 结扎 环氧合酶抑制剂 

分 类 号：R573[医药卫生—消化系统] R657[医药卫生—内科学]