四氯化碳诱导肝硬化模型方法的改进  

Improvement of method of inducing cirrhotic model by carbon totrachloride

作　　者：金峰[1] 张捷[1] 张志坚[1] 余英豪[2] 林克荣[1] 乐桥良[1] 

机构地区：[1]福州总医院消化内科 [2]福州总医院病理科

出　　处：《福州总医院学报》2001年第3期160-161,共2页Journal of Fuzhou General Hospital

摘　　要：目的:建立一种理想的肝硬化模型的复制方法。方法:采用四氯化碳和食用白酒诱导80只雄性SD大鼠。实验期间四氯化碳和食用白酒的浓度在一定范围内逐步增加。观察所有大鼠在经四氯化碳等处理9周后肝脏的病理变化。结果:采用上述方法诱导9周后大鼠死亡率为6.3%,病理检查显示假小叶形成率为92.5%。结论:适度地提高四氯化碳的浓度并采用食用白酒替代医用乙醇溶液诱导大鼠肝硬化模型死亡率低、成功率高。Objective: To investigate an ideal means to induce cirrhotic model in rats. Methods: 80male SD rats were treated with CCl_4 and eatable alcohol. The concentration of CCl_4 and eatable alcohol were increased stage by stage within a right limit during the experiment. All rats were oberved pathological changes of liver after treated with CCl_4 for 9weeks. Results: After induced with above means for 9 weeks, the rat mortality was 6.3%, and pathologica examination showed that fomation rate of livr cirrhosis false lobe was 92.5%. Conclusion: The cirrhotic model in rats were induced by moderately increasing the concentration of CCl_4 and adopting eatable alcohol instead of ethanol has low mortality and high success rate.

关 键 词：肝硬化 诱导 四氯化碳 SD大鼠 死亡率 食用 鼠肝 观察 肝脏 病理检查 

分 类 号：R575.2[医药卫生—消化系统] R285.5[医药卫生—内科学]