^(211)At标记单克隆抗体对移植于裸小鼠体内人胃癌实体瘤导向治疗的初步研究  

PRELIMINARY STUDY ON GUIDING THERAPY OF SUBCUTANEOUS HUMAN HETEROGRAFT IN NUDE MICE BY 211-At LABELLED MONOCLONAL ANTIBODY AGAINST GASTRIC CANCER

作　　者：罗林[1] 王方元[1] 刘宁[2] 张叔渊[2] 金建南[2] 王娟[2] 罗德元[3] 周懋伦[2] 万文徽 董志伟 

机构地区：[1]四川大学生物工程系 [2]四川大学原子核科学技术研究所 [3]华西医科大学肿瘤研究所 [4]北京市肿瘤防治研究所

出　　处：《四川大学学报（自然科学版）》1993年第1期115-119,共5页Journal of Sichuan University(Natural Science Edition)

基　　金：国家自然科学基金资助项目

摘　　要：^(211)At标记的抗人胃癌单克隆抗体3H_(11)对裸小鼠人胃癌移植瘤的生长在短期内有明显抑制作用。治疗后第9天药物对人胃癌生长的抑制作用最为明显^(211)At—3H_(11)(5μCi/只)对人胃癌的抑制率:尾静脉给药为80％,胃癌移植瘤内给药为93％,相同剂量的离子型^(211)At尾静脉给药对胃癌的抑制率为48％.第20天处死动物时^(211)At—3H_(11)尾静脉和肿瘤内给药的抑制率分别是66％和81％,离子型^(211)At尾静脉给药的抑制率为6％,抑制作用明显下降。In short time, 211 - At labelled monoclonal antibody 3H11 inhibited the growth of human gastric cancer grafted in nude mice effectively. The most evident inhibition was observed at the 9th day after treatment, and the tumor inhibition rates were 80%, 93%, 48% in the groups of intravenous injection , internal tumor injection ( both 211 At - 3 H11 5 uCi per animal ) , Na 211At (5uCi per animal)treatment respectively. On the 20th day,when animals were killed,the tumor imbibition rates were 66% ,81% ,6%,respectively. Inhibition treated with Na211At showed obviously lower than those at the 9th day .

关 键 词：胃癌 小鼠 移植瘤 单克隆抗体 

分 类 号：R735.2[医药卫生—肿瘤]