P300作为血管性痴呆早期诊断方法的临床研究  

Clinical study on P300 as the method for early diagnosis of the vascular dementia

作　　者：张宪忠[1] 张秀华[1] 王桂兰[1] 曾维民[1] 王国华[1] 杜玉芬[1] 吴丹[1] 张宗逸[1] 陈兵[2] 

机构地区：[1]哈尔滨医科大学第四临床医院神经内科,黑龙江哈尔滨150010 [2]解放军第309医院神经内科,北京100091

出　　处：《中华老年心脑血管病杂志》2000年第1期28-30,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的　探讨P30 0可否作为血管性痴呆的早期诊断方法。方法　通过对 12 3例血管性痴呆的检测 ,依据 3组年龄段分别与非痴呆组对照 ,并与健康人比较。结果　痴呆组与非痴呆组比较差异有显著性意义 (P <0 .0 5 ) ,而非痴呆组与健康对照组比较差异有显著性意义 (P <0 .0 5 ) ,结果同时显示 ,6 0岁以上痴呆组的P30 0潜伏期延长为对照组潜伏期加年龄附加值加 1.5S以上。部分患者经过早期治疗 ,P30 0潜伏期明显缩短。结论　提示P30 0改变可先于长谷川智力量表 ,作为血管性痴呆的早期诊断方法之一 ,有利于该病的早期发现、诊断和治疗。银杏总黄酮甙 (金纳多 )有利于痴呆的早期治疗。Objective To explore whether P300 can be the method for early diagnosis of vascular dementia.Methods 123 cases of multi infarct dementia(dementia group) were examined and compared with non dementia groups and healthy control groups according to 3 different age ranges respectively.Results There were significant differences between the dementia groups and the non dementia groups(P<0.05) and between the non dementia and the healthy groups(P<0.05).The latent period of P300 in patients over 60 years old of the dementia groups was longer than that in non dementia groups and the healthy controls.The latent period of P300 was prolonged by 1.5 S for every increase in one year of age.Conclusions The results suggest that the change in P300 can occur ealier than that in the intellective score of Haseyakawa Dementia Scales(HDS),P300 can be one of the methods for diagnosis of vascular dementia and favor early diagnosis and early treatment.Early treatment of vascular dementia with Ginaton is effective.

关 键 词：血管性痴呆 早期诊断 事件相关电位 P300 

分 类 号：R749.16[医药卫生—神经病学与精神病学]