复方珍珠滴眼液对兔眼球结膜微循环障碍模型的影响  

Effect of mixed margavite hydrolysafe(MMH) eye drop on the model of microcirculation obstacle in ocular conjunctive in rabbit

作　　者：韩秀娴[1] 吴文耀 邓新国[1] 陈祖基[1] 丁行振[1] 庞广仁[1] 田小莉[1] 付品鹤[1] 

机构地区：[1]河南省眼科研究所,郑州450003 [2]武汉市天天明药业有限责任公司

出　　处：《眼科研究》2001年第3期223-225,共3页Chinese Ophthalmic Research

摘　　要：目的建立兔眼球结膜微循环障碍模型，观察复方珍珠滴眼液（ＭＭＨ）对微循环障碍模型的作用，评价ＭＭＨ改善微循环障碍的可能性。方法采用兔耳静脉注射高分子右旋糖苷的方法建立兔眼球结膜微循环障碍模型。模型组的微循环障碍形成后点用０．９％氯化钠液；ＭＭＨ点眼组（实验组）分别点用对质量浓度及低质量浓度的ＭＭＨ。采用微循环图像处理系统对形态积分、流态积分、毛细血管袢周积分、总积分进行自动分析处理。结果ＭＭＨ对正常兔眼球结膜单次点眼具有增加毛细血管交叉点数、增加血流速度的功效。模型组与ＭＭＨ实验组相比，在形成微循环障碍严重程度方面差异显著。结论用高分子右旋糖苷建立兔眼球结膜微循环障碍模型成功。 ＭＭＨ具有预防微循环障碍的作用。Objective To establish the model of microcirculation obstacle of ocular conjunctiva in rabbit and observe the effect of MMH eye drop on microcirculation obstacle model and appraise the possibility of improvement in microcirculation obstacle by MMH eye drop. Method The model of microcirculation Obstacle of conjunctiva was made by injecting high molecular dextran (molecular weight 21 × 104 ) into ear vein of rabbit. 0. 9% Sodium chloride was used in model group; middle and Low MPH consistence drops were used in experimental groups. The shape integral. nowing shape integral and surroundings of blood capillary integral,etc were automatically analysed by WX-8 microcirculation instrument(Contain picture of automatic management system). Result in normal eye of rabbit the intersection number of blood capillary were increased and the speed of blood now was quick after using MMH eye drop(P <0. 05 ~ 0. 001 ) In model group microcirculation obstacal was more serious than that in the MMH groups(P < 0. 05 ~ 0. 001 ). Conclusion The model of microcirculation obstacle of conjunctiva was successfully established in rabbit. The results suggest that MMH eye drop can prevent conjunctiva from mirocirculation abstacle

关 键 词：微循环障碍模型 球结膜 复方珍珠滴眼液 

分 类 号：R770.2[医药卫生—眼科]