微剂量肝素治疗急性白血病前DIC临床观察  

Research of micro-dose heparin therapy for acute leukemia with pre-diffuse intravascular coagulation

作　　者：汪宝贞[1] 余永卫[1] 周少雄[2] 吴庆庆[1] 周润圻[1] 徐学群[1] 上官辉[1] 

机构地区：[1]广东省佛山市第二人民医院血液内科,528000 [2]广东省佛山市第二人民医院检验科,528000

出　　处：《中国实用内科杂志》2005年第2期157-158,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的　探讨微剂量肝素治疗急性白血病前弥漫性血管内凝血 (pre DIC)的疗效及其安全性。 方法　将 1997- 0 6～ 2 0 0 4 - 0 6佛山市第二人民医院急性白血病前DIC患者 36例 ,随机分成两组 ,微剂量肝素治疗组18例 (A组 ) ,常规治疗组 18例 (B组 )。结果　 10d内 ,A组转化为DIC的患者少于B组 (P <0 0 5 ) ,D D二聚体转阴率A组高于B组 (P <0 0 5 )。结论　微剂量肝素治疗急性白血病前DIC状态能有效的阻止其向DIC发展 ,且具有良好的安全性。Objective To investigate the therapeutic effect and safety of micro-dosage heparin therapy for acute leukemia with pre-diffuse intravascular coagulation (pre-DIC).Methods 36 cases of acute leukemia with pre-DIC were divided into two groups,18 cases were treated with micro-dosage heparin therapy (group A),18 cases were treated with conventional therapy(group B).Results Within the first 10 days,the cases which transformed to diffuse intravascular coagulation (DIC) in group A were significantly lower than group B(P<0.05).The rate of D-dimeride darkening in group A were significantly higher than group B(P<0.05).Conclusion Micro-dosage heparin therapy can effectively interrupt pre-DIC development to DIC.And it has satisfactory safety.

关 键 词：常规治疗 DIC 急性白血病 肝素 剂量 临床观察 D-D二聚体 结论 目的 转化 

分 类 号：R733.71[医药卫生—肿瘤] R759.1[医药卫生—临床医学]