肿瘤间质^(90)Y核素注射量与肿瘤治愈期的关系  

Relationship of tumor therapeutic efficiency of ^(90)Y nuclide to radiopharmaceutical dose

作　　者：陈英茂[1] 耿建华[2] 田嘉禾[1] 姚树林[1] 张书文[1] 陈盛祖[2] 

机构地区：[1]解放军总医院核医学科,北京100853 [2]中国协和医科大学肿瘤医院核医学科,北京100021

出　　处：《肿瘤防治杂志》2004年第4期344-346,共3页China Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金资助项目 ( 3 0 2 70 40 8)

摘　　要：目的 :探讨肿瘤间质注射 90Yβ核素治疗中 ,由治愈期和肿瘤大小确定注射剂量的方法。方法 :依据建立的肿瘤间质注射 β核素治疗过程中的数学模型 ,由计算机模拟实验肿瘤中心注入 0 5mL的 90Y核素治疗时 ,肿瘤组织中形成的吸收剂量、克隆源性细胞存活率的时空分布和肿瘤控制概率 ,观察不同大小的肿瘤在不同剂量的核素治疗时所能达到的治愈期。结果 :1)治愈期与核素注射剂量呈线性 -二次关系 ,并随肿瘤增大而缩短 ;2 )给出了注射剂量与治愈期和肿瘤半径的定量关系式。结论 :对已确定大小的肿瘤 。OBJECTIVE:To explore the radiopharmaceutical dose according to the curable duration for different size tumor in the tumor therapy with 90Y nuclide.METHODS:The process of curing tumor with 0.5 mL 90Y nuclide solution injected into tumor center was simulated with the computer program based on the mathematical model we had built.The therapeutic efficiencies of different radioactivity on different size tumors were evaluated.RESULTS:1)The curable duration varied with radioactivity in quadratic polynomial mode,and decreased with the increase of the tumor size.2)The relationship of the 90Y radioactivity required to the curable duration and the tumor radius was fit to a quantitative expression.CONCLUSIONS:The correct radiopharmaceutical dose injected into the tumor with different size could be determined according to the expected curable duration.

关 键 词：治愈期 肿瘤大小 ^90Y 药物剂量 

分 类 号：R730.5[医药卫生—肿瘤]