XRCC1基因多态性与肺癌易感性关系的研究进展  

Advances of relationship between XRCC1 polymorphisms and lung cancer susceptibility

作　　者：李鸣川[1] 周宝森[1] 

机构地区：[1]中国医科大学流行病教研室,辽宁沈阳110001

出　　处：《肿瘤防治杂志》2004年第4期425-428,共4页China Journal of Cancer Prevention and Treatment

摘　　要：X射线损伤修复的交叉互补基因 (X rayrepaircrosscomplementinggroup 1,XRCC1)是一种DNA损伤修复基因 ,其多态性能够改变DNA修复功能和效率 ,影响肿瘤易感性。分析了XRCC1基因结构。XRCC1,a gene directly involved in repair of DNA damage,contains at least three common polymorphisms.It is possible that these polymorphisms may affect DNA repair capacity and efficiency,thus modulate cancer susceptibility.This paper reviews the structure,function of XRCC1 and advances of the relationship between XRCC1 polymorphisms and lung cancer susceptibility.

关 键 词：XRCC1 肺癌 多态性 

分 类 号：R734.2[医药卫生—肿瘤]