化疗联合放射治疗晚期鼻咽癌的临床研究  

Clinical Application of Chemotherapy Combined With Radiotherapy For Advanced Nasopharyngeal Carcinoma

作　　者：喻建华[1] 万会平[1] 喻建勇[1] 喻瑾瑞[1] 勾安伦[1] 

机构地区：[1]江西省人民医院肿瘤科,330006

出　　处：《实用癌症杂志》2004年第6期634-637,共4页The Practical Journal of Cancer

摘　　要：目的探讨化疗在晚期鼻咽癌治疗中的价值。方法1998年8月～2000年8月,将80例Ⅲ、ⅣA期鼻咽癌患者随机分为单纯放疗组(对照组)和化疗+放疗组(研究组),每组40例,各有20例采用面颈联合野放疗。2组放疗方法、时间/剂量分割均相同。研究组放疗前后行2～6个周期化疗,方案为每天DDP30mg/m2,共1～3天,CF每天200mg/m2,共1～5天,5Fu每天375mg/m2,共1～5天,每3～4周为1个周期。第1个周期诱导化疗结束3天后行放疗,放疗结束后第3天开始行第2～6个周期的辅助化疗。结果研究组和对照组的3年总生存率(OS)及无瘤生存率(DFS)分别为70.0%和57.5%(P>0.05)及59.2%和38.6%(P<0.05);3年局部控制率及无远处转移生存率率分别为81.6%和75.9%(P>0.05)及84.1%和66.1%(P<0.05)。结论放疗联合化疗可提高晚期鼻咽癌患者的无瘤生存率,降低远处转移率,并有改善总生存率的趋势。Objective To evaluate the effect of chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).Methods From August,1998 to August,2000,80 patients with stageⅢ,ⅣA NPC were randomly assigned to receive either simple radiotherapy(RT group,control group,40 cases) or chemotherapy plus radiotherapy(CT+RT group,40 cases).In each group,20 patients received radiotherapy with lateral facio-cervical portals.Radiotherapy technique and dose were same in both groups.In CT+RT group,patients received cisplatin(30 mg/m2/d,days 1～3),Calcium folinate(CF,200 mg/m2/d,days 1～5),5-Fluorouracil(5-Fu,375 mg/m2/d,days 1～5),every 3～4 weeks.The patients received one cycle,followed by radiotherapy.And the cycle was repeated after radiotherapy for 1 to 5 times.Results 3-year overall survival rate(0S) and 3-year disease-free survival rate(DFS) were 70.0% and 59.2% for the CT+RT group,57.5% and 38.6% for the RT group,respectively,showing a significant difference between the two groups(P<0.05).3-year local control rate and 3-year incidence of distant metastasis-free were also markedly different betweeNTHe CT+RT Group and the RT group(81.6%v.s.75.9%,and 84.1% v.s.66.1%)(P<0.05).Conclusion Radiotherapy plus chemotherapy can increase DFS and reduce distant metastasis for patients with locoregionally advanced NPC.It also have a tendency to improve OS.

关 键 词：鼻咽肿瘤 放射疗法 药物疗法 预后 临床研究 

分 类 号：R739.62[医药卫生—肿瘤]