CD34与MMP-2在大肠癌中的表达及其与血管生成的关系  

Expression of CD34 and MMP-2 in colorectal carcinoma and their significance in angiogenesis and metastasis

作　　者：梁青春[1] 魏启幼[1] 李美蓉[1] 张利群[1] 

机构地区：[1]中南大学湘雅二医院病理科,湖南长沙410011

出　　处：《中国现代医学杂志》2005年第2期214-217,共4页China Journal of Modern Medicine

摘　　要：目的探讨CD34与基质金属蛋白酶(MMP-2)在大肠癌组织中的表达及其与肿瘤血管生成、转移的关系。方法应用免疫组化S-P法检测64例大肠癌组织中CD34与MMP-2蛋白的表达及肿瘤微血管计数(MVC)。结果64例大肠癌的MVC值为63.85±24.31,MMP-2阳性表达率为53.13%。MVC与大肠癌的分化程度无相关(P>0.05),与大肠癌的侵袭范围、淋巴结转移相关(P<0.05,P<0.05);MMP-2蛋白表达与大肠癌的分化程度、侵袭范围、淋巴结转移显著相关(P<0.05,P<0.05,P<0.05)。结论癌组织CD34与MMP-2蛋白的表达增强,在肿瘤血管生成、侵袭转移中起重要作用。To determine the significance of CD34 and MMP-2 expression in Colorectal Carcinoma for angiogenesis and metastasis. Streptacidin/Peroxidase(SP) technique was used to examine the expression of CD34 and MMP-2 in 64 cases of Colorectal Carcinoma, and vascular endothelial microvessal count(MVC) was determined by microscopy. The MVC value was 63.85±24.31, with a positive expression rate of MMP-2 53.13%. MVC was not correlated with histopathological grading (P>0.05), but MVC was significantly correlated with invasion range and lymph node metastasis (P<0.05, P<0.05). MMP-2 was significantly correlated with histopathological grading, invasion range and lymph node metastasis (P<0.05, P<0.05, P<0.05). [Conclusions] CD34 and MMP-2 are up-expressed in Colorectal Carcinoma, and tumor angiogenesis plays an important role in the invasion and metastasis of Colorectal Carcinoma.

关 键 词：大肠癌 CD34 MMP-2 微血管计数 

分 类 号：R735.34[医药卫生—肿瘤]