乳腺癌细胞对八种抗癌药物的化疗敏感性  

Chemosensitivity of Eight Anti-cancer Drugs on Breast Cancer Cells

作　　者：喻卫红 蔡玉娥[2] 孟凡娟 李艳萍[2] 逯晓波[3] 

机构地区：[1]辽宁省肿瘤研究所临床肿瘤研究室,辽宁沈阳110042 [2]辽宁省肿瘤医院乳腺病科,辽宁沈阳110042 [3]中国医科大学公共卫生学院卫生系,辽宁沈阳110003

出　　处：《癌变．畸变．突变》2005年第1期45-47,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的:本文研究了不同个体乳腺癌细胞对八种抗癌药物的化疗敏感性。材料与方法:根据临床血浆高峰浓度(1PPC),41例乳腺癌细胞受8种抗癌药物分别作用48 h,采用MTT法的肿瘤细胞抑制率分析了化疗敏感性。结果:在临床血浆高峰浓度(1 PPC)和细胞数为1×105/孔的条件下,乳腺癌细胞的平均抑制率(％)为表柔芘星(EADM)44.30±13.40和米托蒽醌(MTZ)44.14±13.46,其化疗敏感性比其它药物较高,但无统计学意义。8种抗癌药物在肿瘤临床分期和病理分型、淋巴结转移时的化疗敏感性差异有显著性。结论:41例乳腺癌细胞对8种抗癌药物有不同的化疗敏感性。体外MTT法对不同个体乳腺癌进行化疗敏感性预测是必要的。BACKGROUND & AIM: To investigate the chemosensitivity of eight anti-cancer drugs in breast cancer cells of different individual. MATERIAL AND METHODS: The breast cancer cells from 41 patients were being exposed to eight anti-cancer drugs for 48 h, at concentration according to 1 plasma peak concentration (1 PPC) . The inhibition rate of tumor cells was used in vitro MTT assay to determine chemosensitivity. RESULTS: At amount of 1 ×105 tumor cells/ perwell in the present of 1 PPC, the breast cancer cells had higher chemosensitivity to the EADM, MTZ treatment with the inhibition rate of (44.30±10.66) %, (44.14 ±13.05) % than other of drugs, and but they were of no significant. A statistically significant difference was P < 0.01,P < 0.05 and P<0.05 in chemosensitivity of eight drugs between clinical stages, pathology types and lymphoid metastasis. CONCLUSION: Eight anti-cancer drugs had a difference chemosensitivity to the breast cancer cells from 41 patients. The In vitro MTT assay was essential for predicting chemosensitivity of individual breast cancer patients.

关 键 词：抗癌药物 乳腺癌 化疗敏感性 

分 类 号：R737.9[医药卫生—肿瘤]