体外培养骨髓间充质干细胞向成骨细胞分化的影响因素研究  

The factors affecting the differentiation of bone marrow mesenchymal stem cells to osteoblast lineages

作　　者：宋爱梅[1] 束蓉[1] 

机构地区：[1]上海第二医科大学附属第九人民医院,上海200011

出　　处：《牙体牙髓牙周病学杂志》2005年第1期55-58,共4页Chinese Journal of Conservative Dentistry

基　　金：国家"863"计划课题的子课题

摘　　要：探讨影响骨髓间充质干细胞向成骨细胞分化的因素。在骨组织工程中,骨髓间充质干细胞的成骨细胞分化率影响着骨量的形成。本文从诱导条件、细胞密度、支架材料、培养环境等方面综述了影响其向成骨细胞分化的诸多因素,以期为获得更大量的组织工程化骨提供参考依据。To discuss the factors affecting the osteoblastic differentiation of bone marrow mesenchymal stem cells(MSCs) in vitro.In bone tissue engineering,the regeneration of the bone defect is greatly affected by the amount of osteoblasts differentiating from MSCs.Some studies demonstrated that inductive conditions,cell density,scaffold materials,culture environment,etc,could influence the osteogenetic differentiation of MSCs.In order to acquire better bone regeneration with bone marrow MSCs,these factors and their possible osteoinductive mechanism were discussed.

关 键 词：骨髓间充质干细胞 成骨细胞 分化 

分 类 号：R780.2[医药卫生—口腔医学]