复方黄芪提取物抗急性肝损伤作用的研究  

Protection of extract of Radix Atragali composite against acute hepatic injury

作　　者：许华[1] 文洁[2] 俞励平[2] 杨晓明[1] 向继洲[3] 

机构地区：[1]暨南大学药学院,广东广州510632 [2]中山医科大学药物开发中心,广东广州510080 [3]华中科技大学同济医学院,湖北武汉430030

出　　处：《中国病理生理杂志》2005年第2期304-307,共4页Chinese Journal of Pathophysiology

摘　　要：目的 :研究复方黄芪提取物 (ERAC)的抗急性肝损伤作用。方法 :分别采用D -氨基半乳糖 (D -Galn)和四氯化碳 (CCl4)造成急性肝损伤模型 ,检测血清中丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST)的活性及胆红素的含量 ,并进行病理学检查。结果 :ERAC对肝损伤引起的ALT和AST活性增加以及胆红素增高均有明显的降低作用 (P <0 . 0 5 )。病理组织学检查 :ERAC对肝损伤引起的肝细胞变性、坏死等病变有改善作用。结论 :ERAC能减轻D -Galn和CCl4所引起的肝损伤 ,改善肝功能。AIM: To study the protection of extract of Radix Atragali composite against acute hepatic injury. METHODS: Fed with the extract of Radix Atragali composite, m ice were injected with D-galactosamine intraperitoneally (800 mg/kg) and rats were i njected with carbon tetrachloride hypodermically (5 mL/kg) to induce acute hepat ic injury on the 8th day. ALT, AST and bilirubin in serum were examined. Patholo gical changes of liver tissue were observed. RESULTS: Compared with model group, activities of ALT and AST, c oncentrations of bilirubin were markedly decreased and pathological scores also showed that degeneration and necrosis of hepatic cell were lighter in the the ex tract of Radix Atragali composite treatment group. CONCLUSION: The extract of Radix Atragali composite attenuat es hepatic injury induced by D-galactosamine or carbon tetrachloride.

关 键 词：肝损伤 黄芪提取物 半乳糖胺 四氯化碳 

分 类 号：R363[医药卫生—病理学]