扇贝多肽对^(60)Co辐射损伤小鼠的保护作用  

Protective effects of polypeptides from Chlamys farreri on mice irradiated by ^(60)Co γ-ray

作　　者：苗千里 朱莉 陈雪红[3] 韩彦弢[3] 王跃军[4] 孙谧[4] 杜卫[3] 王春波[3] 

机构地区：[1]解放军404医院,山东威海264200 [2]青岛大学医学院附属医院,山东青岛266003 [3]青岛大学医学院,山东青岛266003 [4]中国水产研究院黄海水产研究所,山东青岛266005

出　　处：《中国海洋药物》2005年第1期28-32,共5页Chinese Journal of Marine Drugs

基　　金：青岛市科技局资助项目(No.04 2 HH 69)

摘　　要：采用生物化学方法研讨扇贝多肽(PCF)对小鼠60Co辐射损伤的保护作用。结果表明,PCF能显著 升高60Co辐射小鼠胸腺系数和脾系数;提高组织匀浆中SOD和GSH-Px活性,降低ROS和MDA含量,同时 提高总抗氧化能力,且PCF的作用呈剂量依赖性。提示PCF具有一定的抗辐射作用,这可能与其抗氧化及 能提高机体免疫功能有关。Polypeptide from Chlamys farreri (PCF) have showed protective effect on mice irradiated by 60Co γ- ray in vivo. In present study, the changes of the antioxidative enzyme activities, lipid peroxidation and total antioxidative capacity (T-AOC) in different organs of mice after 60Co irradiation were detected by using biochemical methods. Increased endogenous peroxidation and decreased contents of T-AOC as well as decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were observed after 60Co irradiated mice. Intraperitoneal administration of PCF significantly increased the spleen and thymus indices,decreased the lipid peroxidation, increased T-AOC and the activities of SOD and GSH-Px in all organs tested in 60Co irradiated mice.

关 键 词：扇贝多肽 ^60CO辐射 小鼠 抗氧化 

分 类 号：R931.74[医药卫生—生药学] R979.6[医药卫生—药学]