Analysis of Gene Expression Profile in Lung Adenosquamous Carcinoma Using cDNA Microarray  

作　　者：YANGFei YANGJiong JIANGMan YEBo ZHANGYu-xia CHENHong-lei XIADong LIUMing-qiu 

机构地区：[1]DepartmentofPathology,SchoolofMedicine,WuhanUniversity,Wuhan430071,Hubei,China [2]DepartmentofRespiratoryMedicine,RenminHospital,WuhanUniversity,Wuhan430060,Hubei,China

出　　处：《Wuhan University Journal of Natural Sciences》2004年第6期967-972,共6页武汉大学学报（自然科学英文版）

基　　金：theNationalNaturalScienceFoundationofChina (39870 30 5)

摘　　要：Gene expression profile of the lung adenosquamous carcinoma was characterized by using cDNA microarray chip containing 4 096 human genes. Among target genes, 508 differentially expressed genes were identified in adenosquamous carcinoma of the lung, 232 genes were overexpressed and 276 genes were underexpressed. Among them, 92 genes are cell signals transduction genes, 34 genes are proto-oncogenes and tumor suppressor genes or cell cycle related genes or cell apoptosis related genes, 29 genes are cell skeleton genes, 28 genes are DNA synthesis, repair and recombination genes, 12 genes are DNA binding and transcription genes. These genes may be associated with the occurence and development of adenosquamous carinome of the lung. Key words lung carcinoma - adenosquamous carcinoma - microarray - gene expression profile CLC number R 734.2 Foundation item: Supported by the National Natural Science Foundation of China (39870305)Biography: YANG Fei(1972-), female, Ph. D candidate, research direction: etiology and pathogenesis of lung cancer.Gene expression profile of the lung adenosquamous carcinoma was characterized by using cDNA microarray chip containing 4 096 human genes. Among target genes, 508 differentially expressed genes were identified in adenosquamous carcinoma of the lung, 232 genes were overexpressed and 276 genes were underexpressed. Among them, 92 genes are cell signals transduction genes, 34 genes are proto-oncogenes and tumor suppressor genes or cell cycle related genes or cell apoptosis related genes, 29 genes are cell skeleton genes, 28 genes are DNA synthesis, repair and recombination genes, 12 genes are DNA binding and transcription genes. These genes may be associated with the occurence and development of adenosquamous carinome of the lung. Key words lung carcinoma - adenosquamous carcinoma - microarray - gene expression profile CLC number R 734.2 Foundation item: Supported by the National Natural Science Foundation of China (39870305)Biography: YANG Fei(1972-), female, Ph. D candidate, research direction: etiology and pathogenesis of lung cancer.

关 键 词：lung carcinoma adenosquamous carcinoma MICROARRAY gene expression profile 

分 类 号：R734.2[医药卫生—肿瘤]