Preparation of natural α-tocopherol from non-α-tocopherols  

Preparation of natural a-tocopherol from non-a-tocopherols

作　　者：杨亦文 闻光东 吴彩娟 

机构地区：[1]NationalLaboratoryofSecondaryResourcesChemicalEngineering,ZhejiangUniversity,Hangzhou310027,China

出　　处：《Journal of Zhejiang University Science》2004年第12期1524-1527,共4页浙江大学学报（自然科学英文版）

摘　　要：Non-a-tocopherols are hydroxymethylated and hydrogenated to produce α-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid and 5% Pd/C in an autoclave. Effects of various operation conditions have been studied. The preferable reaction conditions are: temperature 180 ℃ to 200 ℃, pressure 5.0 MPa, acid concentration 0.5 g/100 ml ethanol, mass ratio of Pd/C to tocopherols 7.1 g/100 g, and reaction time 5.0 h. A product with α-tocopherol content of 80% was obtained by using a raw material with a total tocopherols content of 80.54%. The conversion of non-α-tocopherols is almost 100%, and the mole yield of a-tocopherol is more than 90%.Non-a-tocopherols are hydroxymethylated and hydrogenated to produce a-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid and 5% Pd/C in an autoclave. Effects of various operation conditions have been studied. The preferable reaction conditions are: temperature 180℃ to 200℃, pressure 5.0 MPa, acid concentration 0.5 g/100 ml ethanol, mass ratio of Pd/C to tocopherols 7.1g/100g, and reaction time 5.0 h. A product with a-tocopherol content of 80% was obtained by using a raw material with a total tocopherols content of 80.54%. The conversion of non-a-tocopherols is almost 100%, and the mole yield of a-tocopherol is more than 90%.

关 键 词：TOCOPHEROL CONVERSION HYDROXYMETHYLATION HYDROGENOLYSIS 

分 类 号：TQ466.5[化学工程—制药化工]