HYDROXYMETHYLATION

作品数:10被引量:7H指数:1
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相关领域:医药卫生理学更多>>
相关作者:李伟周莹王天麟陈磊王琳琳更多>>
相关机构:南京中医药大学郑州大学第一附属医院南方医科大学更多>>
相关期刊:《Journal of Chemistry and Chemical Engineering》《Chinese Medical Journal》《Journal of Bioresources and Bioproducts》《中国医药工业杂志》更多>>
相关基金:国家自然科学基金国家教育部博士点基金江苏省自然科学基金国家重点基础研究发展计划更多>>
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Epigenetics in psychiatry:Beyond DNA methylation被引量:1
《World Journal of Psychiatry》2023年第6期319-330,共12页Katarina Kouter IrisŠalamon Arčan Alja VidetičPaska 
Supported by Slovenian Research Agency,Young Researcher Grant toŠalamon Arčan I,No.P1-0390,J3-4533,Z3-2653.
The global burden of psychopathologies appears to be underestimated,since the global psychiatric disorder burden is exceeding other medical burdens.To be able to address this problem more effectively,we need to better...
关键词:Mood disorders SUICIDE SCHIZOPHRENIA Bipolar disorder HYDROXYMETHYLATION 5-hydroxymethycytosine Gene expression 
Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients
《World Journal of Gastrointestinal Oncology》2022年第7期1295-1306,共12页Ying-Li Fu Yan-Hua Wu Dong-Hui Cao Zhi-Fang Jia Ao Shen Jing Jiang Xue-Yuan Cao 
Supported by National Natural Science Foundation of China,No.81874279;Scientific and Technological Development Program of Jilin Province,No.20190201093JC and No.20200201326JC;Jilin Province Department of Finance,No.JLSWSRCZX2020-010;Youth Development Fund from First Hospital of Jilin University,No.JDYY11202021.
BACKGROUND Most gastric cancer(GC)patients are diagnosed at middle or late stage because the symptoms in early stage are obscure,which causes higher mortality rates of GC.Helicobacter pylori(H.pylori)was identified as...
关键词:5-hydroxymethylation 5-hydroxymethylcytosine Helicobacter pylori Gastric cancer PROGNOSIS 
Sulfonation of Hydroxymethylated Lignin and Its Application被引量:1
《Journal of Bioresources and Bioproducts》2019年第2期80-88,共9页Weijue GAOD John P.W.INWOODD Pedram FATEHI 
To valorize kraft lignin,hydroxymethylation and sulfonation were applied on this under-utilized,but vastly available,material.The hydroxymethylation pretreatment was conducted as means to improve the reactivity of lig...
关键词:kraft lignin HYDROXYMETHYLATION SULFONATION ADSORPTION dye removal 
Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells被引量:2
《Chinese Medical Journal》2017年第5期594-599,共6页Dan Wang Jin-Hua Huang Qing-Hai Zeng Can Gu Shu Ding Jian-Yun Lu Jing Chen Sheng-Bo Yang 
Background: DNA hydroxymethylation refers to a chemical modification process in which 5-methylcytosine (5mC) is catalyzed to 5-hydroxymethylcytosine (5hmC) by ten-eleven translocation (TET) family proteins. Rec...
关键词:5-hydroxymethylcytosine 5-methylcytosine DNA Hydroxymethylation Ten-eleven Translocation Ultraviolet B 
Kaiso mainly locates in the nucleus in vivo and binds to methylated,but not hydroxymethylated DNA被引量:1
《Chinese Journal of Cancer Research》2015年第2期148-155,共8页Sisi Qin Baozhen Zhang Wei Tian Liankun Gu Zheming Lu Dajun Deng 
supported by National Basic Research Program of China(Grant No.2011CB504201)
Objective: Kaiso is upregulated in many cancers and proposed to bind with both methylated- and unmethylated-DNA in the nucleus as a transcriptional repressor. The objective is to define its subcellnlar localization i...
关键词:Kaiso COMPARTMENTALIZATION DNA binding METHYLATION HYDROXYMETHYLATION CDKN2A 
Liguzinediol的合成被引量:1
《中国医药工业杂志》2014年第3期210-211,共2页周莹 李伟 陈磊 陈施伟 王天麟 
国家自然科学基金(81072542);江苏省自然科学基金(BK2011077);高等学位博士学科点专项基金(20123237110010)
Liguzinediol(1),化学名为2,5-二羟甲基-3,6-二甲基吡嗪,对正常以及急、慢性心力衰竭模型大鼠心脏具有较强的正性肌力作用,且无心律失常等不良反应[1-4]。1可通过作用于心肌细胞内的SERCA2a靶点发挥正性肌力作用[5]。研究表明[6-8],
关键词:LIGUZINEDIOL radical reaction HYDROXYMETHYLATION SYNTHESIS 
Increase of Lignin Reactivity by Means of Depolymerization and Hydroxymethylation for Its Use in Synthetic Wood Elaboration
《Journal of Chemistry and Chemical Engineering》2012年第2期124-137,共14页Alvaro Jimenez Marco Vega Bibiana Gordillo 
Lignin was extracted from peat by Sosa Method. In order to increase its chemical activity, it is necessary to make a structural modification by hydroxymethylation so it can be used in preparation of synthetic wood. De...
关键词:DEPOLYMERIZATION HYDROXYMETHYLATION LIGNIN peat. 
A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin
《Chinese Chemical Letters》2010年第5期568-571,共4页Hai Shan Jin,Li Ming Zhao School of Chemistry and Chemical Engineering,Xuzhou Normal University,Xuzhou 221116,China 
supported by Natural Science Foundation of Xuzhou Normal University(No.08XLB08);Science and Technology Project of Xuzhou(No.XJ09078);Universities Natural Science Foundation of Jiangsu Province (No.09KJD 150006)
Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction.The influence of the amount of solvent,base and formaldehyde toward the hydroxymethylation was discusse...
关键词:Marschalk reaction HYDROXYMETHYLATION EMODIN Antitumor activity 
Preparation of natural α-tocopherol from non-α-tocopherols被引量:1
《Journal of Zhejiang University Science》2004年第12期1524-1527,共4页杨亦文 闻光东 吴彩娟 
Non-a-tocopherols are hydroxymethylated and hydrogenated to produce α-tocopherol in one pot process by simultaneously reacting with paraformaldehyde and hydrogen in the presence of catalysts of benzenesulfonic acid a...
关键词:TOCOPHEROL CONVERSION HYDROXYMETHYLATION HYDROGENOLYSIS 
Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole
《Chinese Chemical Letters》1997年第1期21-24,共4页Cheng He ZHOU Zhi Chang LIU Ru Gang XIE Hua Ming ZHAO(Department of Chemistry, Faculty of Science, Sichuan Union University, Chengdu 610064) 
A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b, new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium...
关键词:Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole 
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