Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients  

作　　者：Ying-Li Fu Yan-Hua Wu Dong-Hui Cao Zhi-Fang Jia Ao Shen Jing Jiang Xue-Yuan Cao 

机构地区：[1]Division of Clinical Research,The First Hospital of Jilin University,Changchun 130000,Jilin Province,China [2]Department of Gastric and Colorectal Surgery,The First Hospital of Jilin University,Changchun 130000,Jilin Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2022年第7期1295-1306,共12页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.81874279;Scientific and Technological Development Program of Jilin Province,No.20190201093JC and No.20200201326JC;Jilin Province Department of Finance,No.JLSWSRCZX2020-010;Youth Development Fund from First Hospital of Jilin University,No.JDYY11202021.

摘　　要：BACKGROUND Most gastric cancer(GC)patients are diagnosed at middle or late stage because the symptoms in early stage are obscure,which causes higher mortality rates of GC.Helicobacter pylori(H.pylori)was identified as a class I carcinogen and leads to aberrant DNA methylation/hydroxymethylation.5-hydroxymethylcytosine(5-hmC)plays complex roles in gene regulation of tumorigenesis and can be considered as an activating epigenetic mark of hydroxymethylation.AIM To explore the association between 5-hmC levels and the progression and prognosis of GC patients with or without H.pylori infection.METHODS A retrospective cohort study was conducted to estimate the predicted value of 5-hmC level in the progression and prognosis of GC patients with different H.pylori infection status.A total of 144 GC patients were recruited.RESULTS The levels of 5-hmC were significantly decreased in tumor tissues(0.076±0.048)compared with the matched control tissues(0.110±0.057,P=0.001).A high level of 5-hmC was an independent significant favorable predictor of overall survival in GC patients(hazard ratio=0.61,95% confidence interval:0.38-0.98,P=0.040),the H.pylori-negative GC subgroup(hazard ratio=0.30,95% confidence interval:0.13-0.68,P=0.004)and the GC patients with TNM stage Ⅰ or Ⅱ(hazard ratio=0.32,95% confidence interval:0.13-0.77,P=0.011).CONCLUSION Increased 5-hmC is a favorable prognostic factor in GC,especially for H.pylori-negative subgroups.

关 键 词：5-hydroxymethylation 5-hydroxymethylcytosine Helicobacter pylori Gastric cancer PROGNOSIS 

分 类 号：R735.2[医药卫生—肿瘤]