A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin  

作　　者：Hai Shan Jin,Li Ming Zhao School of Chemistry and Chemical Engineering,Xuzhou Normal University,Xuzhou 221116,China 

出　　处：《Chinese Chemical Letters》2010年第5期568-571,共4页中国化学快报（英文版）

基　　金：supported by Natural Science Foundation of Xuzhou Normal University(No.08XLB08);Science and Technology Project of Xuzhou(No.XJ09078);Universities Natural Science Foundation of Jiangsu Province (No.09KJD 150006)

摘　　要：Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction.The influence of the amount of solvent,base and formaldehyde toward the hydroxymethylation was discussed.The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product,while the thick reaction solution benefited the generation of the methylated quinizarins.Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction.The influence of the amount of solvent,base and formaldehyde toward the hydroxymethylation was discussed.The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product,while the thick reaction solution benefited the generation of the methylated quinizarins.

关 键 词：Marschalk reaction HYDROXYMETHYLATION EMODIN Antitumor activity 

分 类 号：O621.25[理学—有机化学]