Tracing neuronal tracts in theolfactory pathway of rat anddetecting ischemic core in arat model of focal ischemiausing manganese enhancedmagnetic resonance imaging  

作　　者：FANGKe LIYingxia LIUHua LIAOWeijing LEIHao 

机构地区：[1]StateKeyLaboratoryofMagneticResonanceandAtomicandMolecularPhysics,WuhanInstituteofPhysicsandMathematics,ChineseAcademyofSciences,Wuhan430071,China [2]ZhongnanHospitalofWuhanUniversity,Wuhan430071,China

出　　处：《Chinese Science Bulletin》2004年第17期1834-1840,共7页

摘　　要：Manganese enhanced magnetic resonance im- aging (MRI) is a novel neuroimaging technique that can be used in vivo to trace neuronal tract and to study brain func- tions dynamically. In this study, manganese enhanced MRI was used to trace the neuronal tracts between the laminar structures of the olfactory bulb (OB) in rat and to study the so-called “calcium overload” phenomenon in a rat model of cerebral ischemia. High spatial resolution images of the OB were obtained and used to measure the transportation rate of Mn2+ among the laminar structures of the OB, which was shown to be approximately 0.2 mm/h under resting condition. In the rat focal ischemia study, it was found that the total area of brain regions with Mn2+ accumulation (representing brain regions with calcium overload) was only 55%±15% of the area of the ischemic brain regions shown by diffu- sion-weighted imaging (DWI). Manganese enhanced MRI might be more accurate than DWI in detecting the ischemic core at the early stage of experimental cerebral ischemia.Manganese enhanced magnetic resonance im- aging (MRI) is a novel neuroimaging technique that can be used in vivo to trace neuronal tract and to study brain func- tions dynamically. In this study, manganese enhanced MRI was used to trace the neuronal tracts between the laminar structures of the olfactory bulb (OB) in rat and to study the so-called “calcium overload” phenomenon in a rat model of cerebral ischemia. High spatial resolution images of the OB were obtained and used to measure the transportation rate of Mn2+ among the laminar structures of the OB, which was shown to be approximately 0.2 mm/h under resting condition. In the rat focal ischemia study, it was found that the total area of brain regions with Mn2+ accumulation (representing brain regions with calcium overload) was only 55%±15% of the area of the ischemic brain regions shown by diffu- sion-weighted imaging (DWI). Manganese enhanced MRI might be more accurate than DWI in detecting the ischemic core at the early stage of experimental cerebral ischemia.

关 键 词：MRI 神经元 局部缺血 脑缺血 锰离子 钙离子 嗅球 磁响应图像 

分 类 号：R743.31[医药卫生—神经病学与精神病学]