萘丁美酮干混悬剂的制备及其初步稳定性研究  

Preparation of Nabumetone suspension and preliminary study on its stability

作　　者：陆军[1] 曹芳 纪国宏 李君[4] 

机构地区：[1]江苏省药物研究所,江苏南京210009 [2]南京长澳医药科技有限公司,江苏南京210007 [3]金陵药业股份有限公司,江苏南京210046 [4]南京制药厂有限公司,江苏南京210007

出　　处：《华西药学杂志》2005年第1期26-28,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　制备萘丁美酮干混悬剂。方法　考察常用的羟丙基甲基纤维素、羧甲基纤维素钠、聚维酮、黄原胶、甲基纤维素等辅料对干混悬剂的影响。通过对其沉降体积比、再分散性指标的考察 ,筛选了 2 %HPMC助悬剂 ,并从流变学、混悬剂黏度及显微形态等方面对其稳定性进行了研究。同时考察了药物加速实验下粒子形态的稳定性。结果　所制干混悬剂工艺简单、稳定性良好 ,形成的混悬液符合干混悬剂的各项质量指标。结论　所制备的萘丁美酮干混悬剂可达到干混悬剂要求 ,制剂质量稳定。OBJECTIVE To prepare Nabumetone suspension.METHODS To investigate the suspending effect of the following hydrophilic polymer:HPMC,CMC-Na,PVP K90,Xanthan gum and MC.Two percent of HPMC appeared to be a satisfying suspending agent by evaluating the sedimentation rate and the redispersion of Nabumetone.The mechanism was studied by detecting the rheology property,the difference between suspending medium and suspension,microscopic analysis and the influence of polyelectrolyte,respectively.RESULTS The obtained Nabumetone suspension comformed the quality standard.CONCLUSION The suspension could be used conveniently for clinic.

关 键 词：干混悬剂 萘丁美酮 显微 聚维酮 助悬剂 HPMC 混悬液 制备 沉降体积 粒子形态 

分 类 号：R978.15[医药卫生—药品] R917[医药卫生—药学]