鱼腥草素钠的合成  

Synthesis of sodium houttuyfonate

作　　者：杨劲松[1] 程纯儒[1] 李举联[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第1期30-31,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　研究鱼腥草素钠的工业化生产。方法　以乙酰乙酸乙酯为原料 ,经取代、碱水解及脱羧制得关键中间体甲壬酮 ;再经缩合、加成反应 ,制得鱼腥草素钠 ,总收率 30 .0 %。结果　所得产物的结构经1HNMR和13 CNMR确证 ,其熔点与文献报道的一致。结论　所用方法成本低廉 ,反应条件温和 ,适于工业化生产。OBJECTIVE To study industrial production of sodium houttuyfonate. METHODS We used ethyl acetoacetate as the starting material to prepare sodium houttuyfonate successfully via a three-step procedure resulting in the total yield of 30%.RESULTS The structure of the product was confirmed by 1HNMR and 13CNMR. CONCLUSION This method is convenient for work-up.Its economical and available for industrial production.

关 键 词：总收率 乙酰乙酸乙酯 工业化生产 合成 脱羧 缩合 中间体 鱼腥草素钠 ^1HNMR 碱水解 

分 类 号：R927.2[医药卫生—药学] R917