胸部放疗增加表阿霉素心脏毒性的临床分析  

Radiotherapy increased the eiprubicin Cardiotoxicity in the treatment of the breast carcinoma.

作　　者：陈心华[1] 刘健[1] 李重颖[1] 洪熠[1] 

机构地区：[1]福建省肿瘤医院乳腺癌治疗中心,福建福州350014

出　　处：《现代肿瘤医学》2005年第1期70-71,共2页Journal of Modern Oncology

摘　　要：目的　本文旨在分析胸部放射治疗是否增加表阿霉素的心脏毒性。方法　回顾性分析 128例接受表阿霉素化疗和配合或不配合胸部放射治疗的乳腺癌患者,对其治疗前后的心电图检查结果进行统计学分析。结果　表阿霉素化疗配合胸部放射治疗的乳腺癌患者的心脏毒性明显高于单纯化疗组 (P<0.001);而放化疗组中表阿霉素累积剂量超过 200mg/m2时,心脏毒性明显增加。结论　表阿霉素的心脏毒性与表阿霉素的累积剂量及胸部放射治疗有关。Objective To study the relation facters that influen eiprubicin cardiotoxicity.Methods One hundred and twenty-eight patients with the breast cancer were ebserved. Electrocardiogram was examined before and after each cycle of chemotherapy.The results were analyzed by SPSS10.Results Adriamycin cardiotoxicity was associatied with dose of eiprubicin and radiotherapy.Chest radiotherapy increased the eiprubicin cardiotoxicity.Conclusion Radiotherapy would lead to increase the eiprubicin cardiotoxicity when it was carried out in the patients with breast cancer who were carried out in combined chemotherapy with eiprubicin.The dose of eiprubicin would be loaded down .

关 键 词：表阿霉素 放射治疗 心脏毒性 

分 类 号：R730.55[医药卫生—肿瘤]