中日两城市前列腺癌普查结果及临床病理对比研究  

The comparative study between general investigation results and clinical pathology for prostate cancer in two cities of China and Japan

作　　者：王洪亮[1] 张海峰[1] 许宁[1] 张灵[2] 计国义[2] 李晓萌[2] 高洪文[2] 赵雪俭[2] 桑原正明 

机构地区：[1]吉林大学第一医院泌尿外科,吉林长春130021 [2]吉林大学前列腺疾病防治研究中心 [3]日本宫城县立癌中心泌尿外科

出　　处：《中国老年学杂志》2005年第2期144-146,共3页Chinese Journal of Gerontology

基　　金：中日政府专项技术合作项目(1999);吉林大学青年教师基金(200210)

摘　　要：目的比较中日两城市前列腺癌的发病状况和临床病理情况。方法以长春市3566例和日本名取市2212例55岁以上男性为对象,检测血清前列腺特异抗原(PSA)含量,血清PSA>40ng/ml者行超声引导下系统活检并进行临床病理学诊断。结果(1)长春市受检人群血清PSA>40ng/ml占52%(185/3566人),低于名取市85%(189/2212人)。(2)前列腺癌发现率长春市为08%(28/3566),低于日本名取市21%(46/2212)。(3)PSA>40ng/ml者活检阳性率两市相近,长春市为252%(28/111),名取市为269%(46/171)。(4)临床分期两市相近,长春市局限期癌(T1,T2期)占61%,进展期癌(T3,T4期)占39%,名取市分别为65%和35%。(5)病理分级长春市以中、低分化腺癌为主(89%),名取市以高、中分化癌为主(765%)。结论(1)普查可实现前列腺癌的早期诊断。(2)长春市前列腺癌发现率低于名取市。(3)长春市前列腺癌临床分期与名取市相近,病理分级恶性度高于名取市。Objective To compare the incidence status and clinical pathology of prostate cancer in two cities of China and Japan. Methods 3 566 Chinese and 2 212 Japanese men aged over 55 years accepted general investigation, the men with serum PSA less than ~4.0 ng/ml were conducted ultrasound-guided prostatic biopsy and diagnosed by clinical pathology. Results ①The PSA-positive rate in Changchun (PSA ≥4.0 ng/ml) was 5.2%(185/3 566), lower than that in Natori(8.5%,189/2 212). ②The cancer detective rate in the screened persons of Changchun was 0.8%(28/3 566), lower than that in Natori (2.1%, 46/2 212).③The cancer detective rate by prostate biopsy in Changchun (PSA≥4.0 ng/ml) was 25.2% (28/111) , on the verge of that in Natori (26.9%, 46/171). ④The number and percentage of cases of clinical stage II and III+IV were 61% and 39% in Changchun, close to those in Natori (65% and 35%), respectively. ⑤In regard to the pathological grading, the poorly and middle differentiated cancer were main in Changchun (89%), while the well and middle differentiated cancer were main in Natori(76.5%). Conclusions ①General investigation for prostate cancer could carry out early diagnosis and treatment of prostate cancer. ②The detective rate of prostate cancer in Changchun, China was lower than that in Natori, Japan. ③The clinical pathological grading in Changchun was similar to that in Natori, the extent of poorly differentiated cancer in Changchun was higher than that in Natori.

关 键 词：前列腺特异性抗原 前列腺癌 临床分期 病理分级 

分 类 号：R737.25[医药卫生—肿瘤]