来氟米特加小剂量糖皮质激素治疗激素无效型肾病综合征分析  

Leflunomide combined with low-dosage prednisone in treating ineffective primary nephritic syndrom with prednisone

作　　者：刘云[1] 杨磊[1] 郭明好[1] 

机构地区：[1]新乡医学院第一附属医院肾脏病科,河南卫辉453100

出　　处：《中国现代医药杂志》2004年第6期16-17,共2页Modern Medicine Journal of China

摘　　要：目的探讨来氟米特加小剂量激素治疗激素无效型肾病综合征的近期疗效。方法对15例激素无效型肾病综合征采用来氟米特(前3天50mg/d,以后20mg/d,清晨顿服)加小剂量糖皮质激素治疗,观察3个月后尿蛋白及血浆白蛋白的变化。结果治疗前后血浆白蛋白分别为24.17±4.98g/L和34.76±5.67g/L;24小时尿蛋白定量分别为6.70±2.32g和1.79±1.48g,与治疗前比均有显著差异(P<0.01)。结论来氟米特加小剂量激素是治疗激素无效型肾病综合征的有效方法,值得临床应用。Objective To evaluate the therapeutic effect of leflunomide combined with low-dosage prednisone in treating ineffective primary nephritic syndrome with prednisone. Methods Leflunomide 50mg/d was taken in initial three days and later was taken 20mg/d in 15 patients .At the same time they took 30mg prednisone. The changes of albuminuria and plasma albumin after 3 months were observed. Results Plasma albumin were 24.17±4.98g/L and 34.76±5.67g/L respectively before and after treatment .The quantity of 24 hours albuminuria were 6.70±2.32g and 1.79±1.48g respectively before and after treatment. Both of them were obvious different (P<0.01). Conclusion Leflunomide combined with low-dosage prednisone is an effective method in treating ineffective primary nephritic syndrome with prednisone. It has the potential to be used widely in treating ineffective primary nephritic syndrome with prednisone.

关 键 词：来氟米特 小剂量 糖皮质激素 激素无效型 肾病综合征 PNS 环磷酰胺 

分 类 号：R692[医药卫生—泌尿科学]