辅酶B_(12)模型物与β-环糊精超分子化合物的性质研究  

STUDIES ON THE PROPERTIES OF SUPRAMOLECULES OF COENZYME B_(12) MODELS WITH β-CYCLODEXTRINE

作　　者：刘君[1] 张京君[2] 温新民[1] 陈雁君[1] 

机构地区：[1]济宁医学院化学教研室 [2]济宁医学院附属医院

出　　处：《济宁医学院学报》2000年第4期21-22,共2页Journal of Jining Medical University

摘　　要：目的　研究烷基钴肟类辅酶B12 模型物及其与 β -环糊精形成超分子化合物的性质。 方法　通过核磁共振谱、Co -C键断裂的光分解动力学性质对形成超分子化合物前后的烷基钴肟 (RCo(DH) 2 ·H2 O)辅酶B12 模型物进行了研究。结果　烷基钴肟RCo(DH) 2 ·H2 O中的R基进入了环糊精的腔内 ,钴的平面配体在 β -CD的大口处 ,β -环糊精与RCo(DH) 2 ·H2 O形成了 1:1的超分子化合物 ,且包结前后 ,其Co -C键断裂的光分解反应均按一级反应进行。结论　烷基钴肟与 β -环糊精形成的超分子化合物是适宜的辅酶B12 模型。Objetive To study on the properties of alkylcobaloxime Coenzyme B 12 models and the supramolecular compounds of alkylcobaloxime with β-cyclodextrine (β-CD).Methods Alkylcobaloxime models (RCo(DH) 2·H 2O) and the supramolecular compounds of alkylcobaloxime with β-CD were characterized by HNMR spectroscopy and photolytic kinetics of Co-C bond homolysis.Result It may indicate that R groups of RCo(DH) 2·H 2O were included within the cavities and planars involving Co atom and axime ligand were placed near the wider opening of β-CD.Alkylcobaloxime and β-CD form a kind of 1∶1 adducts.Furthermore it probably sugested that the photolysis of Co-C bond homolysis accord with first order reaction.Conclusion The supramolecular compound of alkylcobaloxime with β-CD is appropriate to coenzyme B 12 model.

关 键 词：辅酶B_(12) 烷基钴肟 Β-环糊精 超分子 光分解 

分 类 号：R313[医药卫生—基础医学] O641[理学—物理化学]