Synthesis and Crystal Structure of 1-Phenyl-3-methyl-4-（4-bromophenyl）-6-（2-chlorophenyl）pyrazolo[3,4-b] Pyridine under Microwave Irradiation  

作　　者：邹翔  屠树江  朱松磊  纪顺俊  张勇  

机构地区：[1]Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu 221009, China,Lianyungang Teacher's College, Lianyungang, Jiangsu 222000, China [2]Department of Chemistry, Xuzhou Normal University, Xuzhou, Jiangsu 221009, China [3]College of Chemistry and Chemical Engineering, Key Lab. of Org.Synth. of Jiangsu Province, Suzhou University, Jiangsu 215006, China

出　　处：《Chinese Journal of Structural Chemistry》2005年第1期6-6,共1页结构化学（英文）

基　　金：国家自然科学基金，江苏省自然科学基金，江苏省重点实验室基金，江苏省重点实验室基金

摘　　要：The title compound (C25H17BrClN3) has been synthesized by the reaction of 1-(2- chlorophenyl)-3-(4-bromophenyl)-2-propylene-1-one with 5-amino-3-methyl-1-phenyl pyrazole under microwave irradiation and its structure was determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P1 with a = 9.3798(11), b = 10.6200(13), c = 11.7433(15) ?, α = 72.932(9), β = 78.877(10), γ = 72.045(9)o, V = 1057.0(2) ?3, Z = 2, Dc = 1.492 g/cm3, μ = 2.088 mm -1 , F(000) = 480, Mr = 474.78, the final R = 0.0428 and wR = 0.0879. X-ray analysis revealed that the dihedral angle between the pyrazol and pyridine planes is 6.45o.The title compound (C25H17BrClN3) has been synthesized by the reaction of 1-(2- chlorophenyl)-3-(4-bromophenyl)-2-propylene-1-one with 5-amino-3-methyl-1-phenyl pyrazole under microwave irradiation and its structure was determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group P1 with a = 9.3798(11), b = 10.6200(13), c = 11.7433(15) ?, α = 72.932(9), β = 78.877(10), γ = 72.045(9)o, V = 1057.0(2) ?3, Z = 2, Dc = 1.492 g/cm3, μ = 2.088 mm -1 , F(000) = 480, Mr = 474.78, the final R = 0.0428 and wR = 0.0879. X-ray analysis revealed that the dihedral angle between the pyrazol and pyridine planes is 6.45o.

关 键 词：AMINOPYRAZOLE PYRAZOLOPYRIDINE crystal structure microwave irradiation 

分 类 号：O6[理学—化学]