中国肝病患者血清铜蓝蛋白水平的研究  

Ceruloplasmin level of patients with liver disease in China

作　　者：杨旭[1] 童德军[1] 梁骏[1] 张永红[1] 雷建华[1] 贺兴鄂[1] 何纲[1] 

机构地区：[1]中南大学湘雅二医院肝病研究中心,长沙410011

出　　处：《中华内科杂志》2005年第1期13-15,共3页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金资助项目 (3 0 170 85 2 )

摘　　要：目的　探讨我国不同肝病患者血清铜蓝蛋白 (CP)水平交叉程度 ,为肝豆状核变性(WD)的诊断和鉴别诊断提供科学的依据。方法　测定 90 5例正常人、WD及其他各种肝病患者血清CP水平 ,采用SPSS12统计软件进行统计分析。结果　WD患者血清CP平均为 (93 9± 98 1)mg/L ,与其他各组相比差异有非常显著性 ,72 7%的患者低于 10 0mg/L ,其中 4 2 9%的患者低于 5 0mg/L ,但是也有 9 1%的患者其血清CP正常 ,其中 3例高于 4 0 0mg/L ,最高达 5 0 1mg/L。 6 8%的非WD患者血清CP低于正常 ,最低为 2 8mg/L。急性肝炎患者血清CP平均为 (398 4± 15 1 3)mg/L ,显著高于其他各组。重型肝炎患者血清CP平均为 (2 96 5± 10 6 5 )mg/L ,显著低于其他各组 ,其中18 8%的患者低于正常。结论　WD患者CP水平显著低于正常人和其他肝病患者 ,但是与其他肝病有一定程度的交叉 ,单凭CP水平不足以确诊或排除WD。Objective To find out the degree of overlap of ceruloplasmin concentration in patients presenting with liver disease, providing scientific evidences for the diagnosis and differential diagnosis of Wilson′s disease (WD).Methods Measuring the serum ceruloplasmin concentration of patients presenting with liver diseases, all data were statistically analyzed with SPSS12 for Windows.Results The average serum ceruloplasmin concentration of patients with WD was (93 9±98 1) mg/L, which was significantly lower than patients with non WD. The ceruloplasmin concentration of 72 7% of patients with WD was less than 100 mg/L, and that of 42 9% of patients with WD was less than 50 mg/L, but the ceruloplasmin concentration of 9 1% of patients with WD was more than 210 mg/L. The average serum ceruloplasmin concentration of patients with acute hepatitis was (398 4±151 3)mg/L, which was significantly higher than other group. The average serum ceruloplasmin concentration of patients with severe hepatitis was(296 5±106 5)mg/L, which was significantly lower than other group. The ceruloplasmin concentration of 6 8% of patients with non WD was less than 210 mg/L, the lowest was 28 mg/L.Conclusions There is some degree overlap in ceruloplamin concentration between WD and other liver disease, WD could not be confirmed or excluded according to ceruloplamin concentration only.

关 键 词：CP 肝病患者 WD 血清铜蓝蛋白 正常人 急性肝炎 肝豆状核变性 中国 平均 水平 

分 类 号：R575[医药卫生—消化系统]