胃肠道间质瘤p21WAF1和Bax表达的临床意义  

Expression of p21WAF1 and Bax in gastrointestinal stromal tumors and its clinical significance

作　　者：戚基萍[1] 徐凤琳[1] 吴爱萍[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院病理科,黑龙江省哈尔滨市150001

出　　处：《世界华人消化杂志》2004年第11期2642-2645,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨p21WAF1和Bax的表达与胃肠道间质瘤的临床病理学特征的关系,分析p21WAF1和Bax在GIST中的作用及其相关性. 方法:应用免疫组化SP法观察40例胃肠道间质瘤中p21WAF1 和Bax的表达情况. 结果:在GIST 40例中,21例表达p21WAF1,阳性表达率为52.5%,p21WAF1阳性信号定位于细胞核;22例表达Bax,阳性表达率55.0%,Bax阳性信号定位于细胞质.p21WAF1和Bax的表达与GIST的性别、年龄、部位、肿瘤大小、有无坏死、组织学分型无关,与组织学分级有关(X2=20.217,P=0.000<0.01;X2=22.896,P= 0.000<0.01).p21WAF1和Bax在潜在恶性和恶性GIST中表达较高,而在良性GIST表达较低(80.0%,80.0%,6.7% 和90.0%,80.O%,6.7%).进一步通过两两比较,良性和潜在恶性之间,良性和恶性之间表达率P21WAF1和Bax表达率有显著差别(P<0.01),但潜在恶性和恶性之间P21WAP1 和Bax的表达率无显著性差异.p21WAF1和Bax的表达具有一定的正相关性(r=0.448,X2=8.021,P=0.005, Kappa=0.447). 结论:p21WAF和Bax在潜在恶性和恶性GIST中发挥作用,但在良性GIST中不发挥作用,二者可作为区别GIST 良恶性的指标.AIM: To investigate the relationship between the expression of p21WAF1 and Bax and clinicopathologic characteristics in gastrointestinal stromal tumors (GIST), and to analyze the role of p21WAFl and Bax in GIST. METHODS: Immunohistochemical SP method was used to detect p21WAFl and Bax expression in 40 cases of GIST. RESULTS: p21WAFl was expressed in the nucleus of 21 cases of GIST (52.5%), and Bax was expressed in the cytoplasm of 22 patients (55.0%). The expression of p21WAFl and Bax had no significant relationship with sex, age of patients, as well as localization, size, necrosis, histo logical typing of GIST, but it significantly related to histo logical grading (X2=20.217, P= 0.000 <0.01; X2=22.896, P= 0.000 <0.01; respectively). There were higher rates of p21WAF1 and Bax expression in potential malignant and malignant GIST than those in benign one (p21WAF1: 80.0 %, 80.0% vs 56.7%, P<0.01; Bax: 90.0%, 80.0% vs 6.7%, P<0.01). The difference of p21WAFl and Bax expression between potential malignancy and malignancy was not significant. There was a positive correlation between p21WAF1 and Bax expression (r= 0.448, X2=8.021, P = 0.005<0.01, Kappa=0.447) in GIST. CONCLUSION: The expression of p21WAFl and Bax plays an important role in the pathogenesis of potential malignant and malignant GIST, but not in benign GIST, which may be used as an index to differentiate benign GIST from potential malignant and malignant ones.

关 键 词：胃肠道间质瘤 P21WAF1 BAX 表达 发病机制 

分 类 号：R735[医药卫生—肿瘤]