Survivin蛋白和PCNA在鼻咽癌中的表达及其临床意义  

Expression and Clinical Signficance of Survivin and PCNA in Nasopharyngeal Carcinoma

作　　者：邹继彬[1] 黄广恩[1] 陈中坚[1] 陈鸿莲[1] 

机构地区：[1]广东省湛江中心人民医院病理科,广东湛江524037

出　　处：《中国医师杂志》2004年第12期1636-1638,共3页Journal of Chinese Physician

摘　　要：目的　研究survivin蛋白和PCNA在鼻咽癌 (NPC)组织中的表达 ,探讨它们之间的关系 ,并了解其临床意义。方法　应用免疫组织化学SP法检测 96例鼻咽癌组织中survivin和增殖细胞核抗原 (PCNA)蛋白的表达水平。结果　鼻咽癌组织中有survivin蛋白的表达 ,其阳性表达率为 75 0 % (72 /96) ;survivin蛋白表达阳性的鼻咽癌细胞PCNA的标记指数高于survivin蛋白表达阴性者 ;有颈淋巴结转移的鼻咽癌中survivin蛋白阳性率高于无颈淋巴结转移者 ;生存年限 <5年的survivin蛋白阳性表达率比生存年限 >5年的高。结论　鼻咽癌组织中有survivin蛋白的表达 ,其表达与PCNA有关 ;survivin蛋白能促进鼻咽癌颈淋巴结转移 ;Objective To explore the expression and clinical significance of survivin protein and proliferation cell nuclear antigen(PCNA) in human nasopharyngeal carcinoma (NPC). Methods The expression of survivin protein and PCNA was detected by SP immunohistochemical technique in 96 cases of NPC tissues. Results The positive rate of survivin expression was 75.0% in PNC. Labeling idex(LI) of PCNA in survine positive NPC was higher than that in survivin negative NPC. The positive rate of survivin expression in NPC with neck lymph node metastasis was higher than that in NPC without neck lymph node metastasis. The positive rate of survivin expression in NPC patients with less than 5-year survival rate was higher than that in NPC patients with over 5-year survival rate. Conclusion NPC had survivin expression, and survivin expression in NPC was positive related with PCNA expression. The survivin protein might promote the neck lymph node metastasis of NPC cells. The prognosis of the patients with survivin positive NPC was worse.

关 键 词：SURVIVIN蛋白 PCNA 阳性表达率 鼻咽癌组织 临床意义 颈淋巴结转移 鼻咽癌细胞 表达水平 生存 阳性率 

分 类 号：R739.63[医药卫生—肿瘤]