草酸铂与时间调节5-氟脲嘧啶/亚叶酸钙治疗转移性结直肠癌疗效  

The effect of treatment of Metastatic carcinoma of the colon and rectum using L-OHP and timing 5-Fu/CF

作　　者：杨燕霞[1] 鲍力[1] 毋永娟[1] 樊圣[1] 

机构地区：[1]包头市第七医院肿瘤内科,内蒙古包头014030

出　　处：《临床肿瘤学杂志》2005年第1期61-63,共3页Chinese Clinical Oncology

摘　　要：目的:观察草酸铂(L-OHP)与时间调节5-氟脲嘧啶/亚叶酸钙(5-Fu/CF)治疗发生转移的结直肠癌疗效。方 法:对同周期经病理组织学或细胞学证实发生转移的结直肠腺癌44例,随机分为试验组和对照组,采用静脉多通道的时间编 程泵给药。试验组采用时辰化疗方法,L -OHP150mg/m2在用药第1天10时至16时给药,持续6小时静脉滴注,CF100mg/ m2d1～5,5-Fu500mg/m2d1～5,用药时间在每天22时15分至次日9时45分连续静脉滴注给药。对照组用药L-OHP150mg/m2 每日上午9时～12时静滴,CF100mg/m2d1～5,5-Fu500mg/m2d1～5,持续静脉滴注24小时。两组化疗前均给予恩丹西酮8mg 或格拉司琼3mg静注预防性止吐药。21天为1周期。在每个治疗周期开始前记录前1周期的毒性,并根据WHO标准分级。 每6个治疗周期后根据WHO标准评定疗效及毒副反应。结果:试验组22例,总有效率(CR+PR)54.5%。对照组22例,总 有效率(CR+PR)31.8%。两组疗效相比,有显著性差异(P<0.01)。毒副反应:外周静脉炎,试验组13.6%,对照组45.5%; 周围神经毒性,试验组36.4%,对照组81.8%,两组结果统计学处理有显著性差异(P<0.01);骨髓抑制、胃肠道反应、口腔溃 疡、脱发,两组结果无显著性差异(P>0.05);未见肝肾功、心功能损害。结论:草酸铂与时间调节5-Fu/CF治疗发生转移的结 直肠癌?Objective:To Observe the effect of treatment of Metastatic carcinoma of the colon and rectum by using L-OHP and timing 5-Fu/CF.Methods:We randomly separated 44 patients with carcinoma of the colon and rectum which had metastasis proved by examination of pathology and cytology into the group of experiment and group of contrast.We used the timing pump of three-way pipe to infuse drugs to patients.The group of experiment used the method of timing chemotherapy:L-OHP 150mg/m 2, ivgtt,day 1,continues from 10 am to 4pm;CF 100mg/m 2,ivgtt,day 1-5;5-Fu 500mg/m 2 ivgtt,day 1-5,Both the latters continued from 22∶15 pm to 9∶45 am everyday.The group of contrast used the methods:L-OHP 150mg/m 2,day 1;CF 100mg/m 2,day 1-5,and 5-Fu 500mg/m 2,day 1-5.Both the latters continued 24 hours.Both experiment group and contrast one used Ondansetron 8mg or Granisetron 3mg to prevent vomiting.Every cycle was 21 days.Six cycles were a complete course.After six cycles of chemotherapy, we evaluated the effects and side effects in accordance with WHO criteria.Before every cycle started, we recorded the toxicity of last chemotherapy and graded toxic side-effect in accordance with WHO criteria.Results:CR+PR accounted for 31.8% in 22 patients of contrast group.CR+PR accounted for 54.5% in 22 patients of experiment group.Two results were examined with χ 2 and they had obvious difference(P<0.01);Side-effect:1)peripheral phlebitis:13.6% in experiment group and 45.5% in contrast one.2)The hurt of periphecal nerves:36.4% in experiment and 81.8% in contrast.Two results had obvious difference (P<0.01).3)Two group's results had no difference (P>0.05) in inhibition of narrow,effect on gastrointestinal tract and trichomadesis.4)The function of liver,kidney and heart have not been hurt.Conclusion:The way to treat the colon and rectum carcinoma with metastasis by using L-OHP and timing 5-Fu/CF is superior to that of infusion of them in vein in short time,preventing hurting peripheral nerve endings and other side-effects and raising the tolerance

关 键 词：治疗 对照组 结直肠癌 疗效 5-FU 给药 草酸铂 5-氟脲嘧啶 亚叶酸钙 总有效率 

分 类 号：R735[医药卫生—肿瘤] R737[医药卫生—临床医学]