身体质量指数及腰臀围比与胆道癌关系的探讨  

Body Mass Index (BMI), waist to hip ratio (WHR) and risk of biliary tract cancers: A population-based Case-control Study in Shanghai

作　　者：张学宏[1] 高玉堂[1] Asif Rashid 邓杰[1] 刘恩菊[1] 邬恺[1] 孙璐[1] 程家蓉[1] Gloria Gridley Ann W Hsing 

机构地区：[1]上海市肿瘤研究所,上海市200032 [2]美国M.D.Anderson癌症中心 [3]美国国立癌症研究所

出　　处：《中国肿瘤临床》2005年第4期227-230,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨身体质量指数(BMI)、腰臀围比(WHR)与胆道癌的关系。方法:采用非条件logistic回归模型分析身体质量指数、腰臀围比与胆道癌的关系。结果:与正常BMI组比较,胆囊癌女性20～29岁、30～39岁肥胖组的OR与趋势检验均达到或接近显著水平。与腰臀围比四分位最低组比较,胆囊癌和肝外胆管癌男女性最高四分位组OR和趋势检验均达到显著水平。结论:青年时期肥胖可能会增加胆囊癌的发病风险;腰臀围比也是胆囊癌和肝外胆管癌独立的危险因素。Objective: To investigate the relationship between the body mass index (BMI), the waist to hip ratio (WHR) and the biliary tract cancers. Methods: Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: Obesity was associated with increased risk of gallbladder cancer across adulthood for being obese at ages 20~29 and 30~39 among females. Compared to the subjects with the lowest quartile of WHR, ORs for highest quartile and P for trend both reached significant level among males and females. Conclusion: Our observations in urban Shanghai suggest that obesity in early adult life, may contribute to the risk of gallbladder cancer. And increased WHR may substantially elevated risk of cancers of the gallbladder and extrahepatic bile duct as well.

关 键 词：胆道癌 身体质量指数 腰臀围比 病例对照研究 

分 类 号：R735.8[医药卫生—肿瘤] R735.8[医药卫生—临床医学]