中国乙型肝炎病毒B基因型、C基因型与干扰素疗效的关系  

The relation between chinese hepatitis B virus genotype B C and efficacy of interferon-α.

作　　者：李庭明[1] 朱幼芙[1] 何海棠[1] 毛乾国[1] 吴爱华[1] 梁蔚芳[1] 骆抗先[1] 

机构地区：[1]南方医科大学附属南方医院感染内科,广东广州510515

出　　处：《临床肝胆病杂志》2005年第1期16-18,共3页Journal of Clinical Hepatology

基　　金：军队九五研究基金 (NO.0 1Z0 4 6)

摘　　要：探讨中国乙型肝炎病毒基因型与干扰素α疗效的关系。用PCR -限制性酶切片段长度多态性方法分析乙型肝炎病毒基因型 ,并研究 1998 1～ 2 0 0 2 4南方医院门诊和住院慢性乙型肝炎患者的一般人口学、ALT、HBVDNA、肝脏活检组织病理以及干扰素治疗效果。B基因型 70例 ,C基因型 6 0例 ,两基因型间一般人口学、ALT、HBVDNA、肝脏活检组织病理无统计学差异 ,干扰素治疗效果同样没有显著性差异。HBVB、C基因型感染的慢性乙型肝炎患者临床无统计学差异 。To investigate the relation between chinese hpatitis B virus (HBV) genotype and efficacy of interferon-α.HBV genetype was testified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Common demography,Alanine aminotransferase (ALT),HBVDNA,liver biopsy,and efficacy of interferon-α of chronic hepatitis B(CHB)patients of Nanfang Hospital during 1998.1-2002.4 were surveyed.Patients with CHB caused by HBV B or C genotype have not any significante difference neither in common demography,ALT,HBV DNA,liver biopsy,nor in efficacy of interferon-α Patients infected with HBV B or C genotype have no significante difference in clinic,probably correlated to the similar immune background of two groups.

关 键 词：C基因 疗效 活检组织 B基因 干扰素治疗 慢性乙型肝炎患者 乙型肝炎病毒基因型 显著性差异 研究 切片 

分 类 号：R512.62[医药卫生—内科学] R373[医药卫生—临床医学]