高血压发展过程中脑血管平滑肌细胞离子通道的变化  

Alterations of ion channels in cerebrovascular smooth muscle cells during hypert ension

作　　者：史小莲 关永源[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广东广州510089

出　　处：《中国药理学通报》2005年第2期129-132,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30271503)

摘　　要：脑血管重构是高血压发展过程中最重要的病理生理改变,由此引起的脑卒中更日益危害人类的健康。在高血压发展过程中,脑血管平滑肌细胞上分布的多种离子通道,如钾钙、氯等均发生变化,导致细胞内离子浓度异常,在脑血管重构的发生发展过程中发挥了重要作用。Cerebrovascular remodeling is the most important pathologic change during hypertension. Stroke induced by hypertension is threatening thousands of people's lives. The ion channels in cerebrovascular smooth muscle cells may be altered during hypertension and thus the abnormality of cytosolic ion concentration can accelerate cerebrovascular remodeling. These channels, including potassium channels, calcium channels and chloride channels, may play an important role in the cerebrovascular remodeling during hypertension.

关 键 词：脑血管 平滑肌细胞 高血压 钾通道 钙通道 氯通道 

分 类 号：R-05[医药卫生] R322.12