早期植骨修复腭裂对上颌骨生长影响的实验研究  

The influence of autogenous bone graft in cleft palate on maxillary growth: an experiment study in rats

作　　者：王予江[1] 童永青[1] 戴群[1] 陈爱国[1] 梁凯[1] 

机构地区：[1]江西医学院附属口腔医院口腔颌面外科,江西南昌330006

出　　处：《上海口腔医学》2005年第1期37-41,共5页Shanghai Journal of Stomatology

基　　金：江西省教育厅基金(F010701)

摘　　要：目的:探讨大白鼠人造腭裂行早期自体骨移植修复对上颌骨生长发育的影响。方法:选取40只4周龄的雄性Wistar大白鼠,随机分为4组,即正常对照组、人造腭裂组、人造腭裂两瓣法修复组、人造腭裂自体骨移植加两瓣法修复组;每组10只。术后10周观察上颌骨的生长发育指标,应用SPSS软件进行统计学处理,再行组间方差分析。结果:上颌骨宽度指标、最大上颌骨长度指标(A-D)、上颌骨高度指标值,植骨修复组均显著小于正常组与人造腭裂组,有统计学意义(P﹤0.01)。两侧硬腭后份宽度指标,植骨修复组显著大于两瓣修复组,有统计学意义(P﹤0.01);其余多项指标,植骨修复组与两瓣修复组均无显著性差异(P﹥0.05),但上颌骨高度的3项指标和长度指标(AD)均值,植骨修复组均小于两瓣修复组。结论:人造腭裂行自体骨移植修复对上颌骨的横向生长有积极意义,但对上颌前后向、垂直向的生长发育较两瓣修复法有进一步受限的倾向。PURPOSE: This study was designed to investigate the influence of autogenous bone graft in cleft palate on maxillary growth in rats. METHODS: Forty Wistar strain male rats aged 4 weeks were randomly divided into four groups. Each group had 10 rats. Group 1 was the unoperated control group. Group 2 had a surgically created cleft palate but unrepaired. Group 3 also had a surgically created cleft palate which followed by a two-flap palatoplasty repair immediately. Group 4(experimental group) also had a surgically created cleft palate,but the cleft palate was reconstructed by autogenous rib graft with two-flap repair. All animals were sacrificed on the 10th week after operation. The data were analyzed using SPSS. And one-way ANOVA was used for comparison of the four groups. RESULTS: The experimental group was significantly smaller than unoperated control group and cleft palate group in the maxillary widths variables,length variables (AD),height variables(P<0.01).Except rats in the experimental group had significantly greater posterior palate width than rats in two-flap repair group(P<0.01),there were no significant difference between the two procedures in maxillary growth variables(P>0.05).But the experimental group was smaller in the maxillary heights,length variables than the two-flap group. CONCLUSIONS: These findings showed that repair of the cleft palate by autogenous rib graft had positive effect on preventing the contraction of maxillary width. But in the maxillary anteroposterior and vertical development,the experimental group possibly had more severe retardation than two-flap repair group.

关 键 词：上颌骨 腭裂 植骨 生长发育 大白鼠 

分 类 号：R782.2[医药卫生—口腔医学]