肝硬化、肝癌患者血清sFas和TGF-β_1水平的探讨  

Study on serum level of sFas and TGF-β_1 in patients with HBV related eirrhosis of liver and hepatocellular carcinoma

作　　者：林向阳[1] 吴娅娅[1] 陶志华[1] 陈晓东[1] 沈关心[2] 吴健民[3] 

机构地区：[1]温州医学院附属第一医院检验科,浙江温州325000 [2]华中科技大学同济医学院免疫教研室 [3]华中科技大学同济医学院附属协和医院检验科

出　　处：《中国实验诊断学》2005年第1期102-104,共3页Chinese Journal of Laboratory Diagnosis

基　　金：浙江省温州市科委项目资助 (课题批号 :S2 0 0 2A12 9)

摘　　要：目的　探讨血清可溶性Fas(sFas)和转化生长因子 β1(TGF β1)水平的变化与乙肝后相关性肝硬化、肝癌的关系。方法　对 2 0例肝炎、2 8例HBV相关性肝硬化及 2 0例肝癌患者血清sFas、TGF β1、血清透明质酸、Ⅲ型前胶原、Ⅳ型胶原进行检测 ,同时对其中 4 3例慢性乙肝和肝硬化患者进行HBV DNA的定量检测。结果　HBV相关性肝硬化、肝癌患者血清sFas和TGF β1水平明显升高 ,与正常对照比较 ,差异有显著意义 (P <0 0 5 ) ;并且其结果与肝纤维化指标有一定的相关性 ;而慢性肝炎、肝硬化患者血清sFas和TGF β1水平与HBV DNA复制程度无显著关系。结论　乙肝后肝硬化、肝癌的发展进程可能与血清sFas及细胞因子TGF β1水平密切相关 ,而与血浆中HBV复制程度无显著关系。Objective To study the relationship between the level of soluble Fas(sFas) and TGF β 1 in serum and hepatitis B virus(HBV) related cirrhosis of liver as well as hepatocellular carcinoma(HCC). Methods sFas, TGF β 1, Hyaluronic Acid, Procollagen TypeⅢ, TypeⅣ Collagen in serum were measured in 20 patients with hepatitis B, 28 patients with HBV related cirrhosis of liver, and 20 patients with HCC, at the same time pick out 43 patients with chronic hepatitis B and cirrhosis of liver to detect serum HBV DNA. Results Compared with normal control, the sFas and TGF β 1 level in serum of patients with HBV related cirrhosis of liver and HCC were both significantly increased( P <0 05), and the results correlated closely with the molecules of liver fibrosis, whereas, the sFas level in serum of patients with chronic hepatitis B and cirrhosis of liver were not significantly correlated with replication of serum HBV DNA. Conclusion The development of HBV related hepatocirrhosis and HCC may have a close relationship with the changes of sFas and TGF β 1, however, which was not significantly related to serum HBV replication.

关 键 词：乙型肝炎 可溶性FAS 凋亡 TGF-Β1 

分 类 号：R575.2[医药卫生—消化系统] R735.7[医药卫生—内科学]