血管生长素在胃癌血管生成中的作用  

Effect of Angiogenin on Angiogenesis in Gastric Carcinoma

作　　者：陈瑜[1] 张声[2] 陈余鹏 林建银[3] 

机构地区：[1]福建医科大学基础医学院生理与病理生理学系,福建福州350004 [2]福建医科大学附属第一医院病理科,福建福州350005 [3]福建医科大学分子医学研究中心,福建福州350004

出　　处：《癌症》2005年第3期317-320,共4页Chinese Journal of Cancer

基　　金：福建省自然科学基金资助项目(No.C0110013);福建省科技重大项目(No.2002Y003)~~

摘　　要：背景与目的:血管生长素(angiogenin,ANG)是一种有效的促血管生成素,资料显示结肠癌、胰腺癌等肿瘤ANG表达增强,但ANG在肿瘤性血管生成中的作用尚不清楚。本研究探讨ANG在胃癌血管生成中的作用。方法:运用免疫组化方法检测68例胃癌组织中ANG、CD34和Ki-67的表达,根据CD34的染色情况计算出胃癌组织的微血管密度(microvesseldensity,MVD),根据Ki-67的染色情况计算出肿瘤细胞Ki-67标记指数。结果:在胃癌组织中,19例ANG强阳性组织中MVD(308.4±25.6)明显高于3例ANG阴性组(196.0±31.3)(P<0.01)。ANG蛋白阳性组的Ki-67标记指数(579.6±31.4)明显高于ANG蛋白阴性组(341.3±84.0)(P<0.01)。结论:癌组织ANG蛋白表达水平与MVD呈正相关,癌组织ANG表达水平与胃癌细胞标记指数正相关。BACKGROUND & OBJECTIVE: Angiogenin (ANG), an efficient angiogenesis factor, is up-regulated in human colorectal carcinoma, pancreatic carcinoma, and other tumors. But the function of ANG in tumor angiogenesis is still unknown. This study was to explore the effect of ANG on angiogenesis of gastric carcinoma. METHODS: The expressions of ANG, CD34, and Ki-67 in 68 specimens of gastric carcinoma were detected by immunohistochemistry. Microvessel density (MVD) was figured out according to the expression of CD34. The proliferation index of carcinoma cells in gastric carcinoma tissue was figured out according to the expression of Ki-67. RESULTS: Of the 68 specimens of gastric carcinoma, 19 showed strongly positive expression of ANG (group A), 3 showed negative expression of ANG (group B). MVD of group A was significantly higher than that of group B (308.4±25.6 vs. 196.0±31.3, P<0.01). Proliferation index of group A was significantly higher than that of group B (579.6±31.4 vs. 341.3±84.0, P<0.01). CONCLUSION: Protein level of ANG positively correlates with MVD of gastric carcinoma tissue, and proliferation index of carcinoma cells.

关 键 词：胃肿瘤 血管生长素 血管生成 

分 类 号：R735.2[医药卫生—肿瘤]