胰岛素样生长因子-1的神经保护作用  

The Neuroprotective Effects of Insulin-Like Growth Factor-1

作　　者：韩彩萍[1] 胡长林[1] 

机构地区：[1]重庆医科大学附属第二医院神经内科,400010

出　　处：《国外医学（脑血管疾病分册）》2005年第1期46-49,共4页Foreign Medical Sciences Cerebrovascular Diseases

摘　　要：胰岛素样生长因子- 1(IGF- 1)是一种多肽类神经营养因子。在生理条件下,IGF- 1及其受体广泛分布于中枢神经系统;在病理条件下,IGF -1表达上调,并通过促分裂原活化蛋白激酶和磷脂酰肌醇3 激酶/丝氨酸-苏氨酸蛋白激酶等信号通路,抑制细胞凋亡、调节离子通道活性、抑制一氧化氮毒性等多种途径发挥神经保护作用。Insulin-like growth factor-1 (IGF-1) is a polypeptide neurotrophic factor. Under the physiological condition, IGF-1 and its receptor are widely distributed in the central nervous system, and under the pathologic condition, the expression of IGF-1 is upregulated. IGF-1 inhibits cell apoptosis, regulates ion channel activity and inhibits the nitric oxide toxicity via mitogen-activated protein kinase and phosphatidyl inositol 3 kinase /serine-threonine protein kinase signaling pathways, thus exerts neuroprotective effects.

关 键 词：胰岛素样生长因子-1 IGF-1 神经保护 磷脂酰肌醇3-激酶 神经细胞 

分 类 号：R741[医药卫生—神经病学与精神病学]