喉癌患者血清巨噬细胞集落刺激因子的检测  

The serum level of macrophage colony stimulating factor in laryngeal carcinoma patients

作　　者：葛平江[1] 张宝泉[2] 张建民[3] 孔庆利[3] 高志强[2] 王辉[2] 何维[3] 

机构地区：[1]广东省人民医院耳鼻咽喉头颈外科,广东广州510080 [2]中国医学科学院中国协和医科大学北京协和医院耳鼻咽喉头颈外科,北京100730 [3]中国医学科学院基础研究所免疫室,北京100730

出　　处：《中国耳鼻咽喉头颈外科》2005年第1期21-24,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家973 重点课题(2001CB5100009)

摘　　要：目的通过对喉癌患者外周血巨噬细胞集落刺激因子(M-CSF)进行检测,探讨M-CSF对肿瘤的影响及其作用机理。方法用ELISA法检测31例喉鳞状细胞癌患者和17例年龄和性别匹配的正常对照者血清中的M-CSF、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的浓度,并进行统计学分析。结果31例喉癌患者血清中M-CSF浓度(341.37±80.57pg/ml)较17例正常对照(281.22±72.11pg/ml)升高(P<0.05),而且在癌转移患者中浓度更高(P=0.036)。结论喉癌患者血清中M-CSF浓度升高,且同肿瘤的淋巴结转移有关,浓度越高转移的可能性就越大。OBJECTIVE To investigate the serum level and possible role of macrophage colony stimulat- ing factor(M-CSF) in the laryngeal carcinoma patients. METHODS The serum were obtained from 31 laryn- geal carcinoma patients. The level of M-CSF, IL-1 β, TNF- α,IL-6 of serum in patients were measured in duplicated by a ELISA technique. The clinical data were analysised. RSESULTS The mean serum M-CSF level for the 31 patients with laryngeal carcinoma was 341.37 ± 80.57pg/ml,statistically higher than that of the con- trols 281.22 ± 72.11pg/ml (P = 0.04). The serum lev- els of M-CSF of metastasis patients were higher than others in all of laryngeal cancer patients. CONCLUSION The results suggest that higher M-CSF serum levels may present in most laryngeal carcinoma patients. [

关 键 词：患者 喉癌 M-CSF 血清 肿瘤坏死因子A 巨噬细胞集落刺激因子 正常 升高 对照 TNF—α 

分 类 号：R739.65[医药卫生—肿瘤] R737[医药卫生—临床医学]