银杏叶片治疗燃煤型砷中毒肝纤维化的临床研究  

Clinical Study on Treatment to Hepatic Fibrosis of Coal-Brunt Arsenic with Ginkgo Leaf

作　　者：何云[1] 张爱华[2] 杨大平[1] 王建宾[1] 韦小瑜[1] 黄晓欣[1] 

机构地区：[1]解放军第44医院,贵阳550009 [2]贵阳医学院公共卫生院,贵阳550004

出　　处：《西南军医》2005年第1期1-3,共3页Journal of Military Surgeon in Southwest China

基　　金：全军"十.五"科研攻关面上项目;No :0 1MA0 48;成都军区"十.五"医药卫生科研课题 ( 0 1A0 0 1)

摘　　要：目的　研究银杏叶片抗燃煤型砷中毒肝纤维化作用。方法　选择燃煤型砷中毒高发区 84例慢性砷中毒患者 ,银杏叶片治疗 3月 ,对照组用安慰片。检查治疗前后患者血清PAF及四项肝纤维化指标 ,部分患者作治疗前后的病理学检查。结果　治疗组血清PAF及四项肝纤维化指标治疗后较治疗前有明显降低 (P <0 .0 1)。治疗组的显效率和总有效率分别为 4 5 .5 %和 79.5 % ,而对照组的显效率和总有效率分别是 17.5 %和 4 2 .5 % ,两者比较有显著性差异 (P <0 .0 1)。治疗组治疗后的肝脏病理有一定的改善。Objective To study the anti-hepatic fibrosis effect of Ginkgo leaf in patients with coal-brunt arsenic.Methods Eighty-four patients of coal-brunt arsenic were randomly divided into two groups:treated group and control group.All the patients were treated for 3 months,patients in treated group with Ginkgo leaf while patients in control group with comfort tablets.Serum PAF and four hepatic fibrosis parameters were studied before and after treatment,and pathological study was given to some patients.Results The level of Serum PAF and the four hepatic fibrosis parameters were much lower in treated group after treatment than those before treatment (P<0.01).The effectual rate and total effective rate reached 17.5% and 42.5%,the difference was significant.The pathological examination showed certain improvement of liver in patients of treated group.Conclusions Ginkgo leaf tablet has the anti-hepatic fibrosis effect.

关 键 词：燃煤型砷中毒 肝纤维化 血小板活化因子 银杏叶片 

分 类 号：R575[医药卫生—消化系统]