乳腺导管内癌围管性微血管密度与浸润的关系  

Periductal microvessel density and invasion in ductal carcinoma in situ of breast

作　　者：邬万新[1] 温晓伟[1] 张燕萍[1] 钱建育[1] 唐正英[1] 王振[1] 

机构地区：[1]浙江嘉兴学院附属第一医院病理科,嘉兴314000

出　　处：《实用肿瘤学杂志》2005年第1期3-6,共4页Practical Oncology Journal

摘　　要：目的　评价围管性微血管密度(MVD)在预测乳腺导管内癌向浸润性癌转化中的价值。方法　6 2例乳腺癌(包括单纯导管内癌12例、伴浸润癌导管内癌13例和浸润性癌37例)进行CD34和F8免疫组化染色,并采用计算机图象分析方法定量乳腺癌微血管密度。同时,对微血管密度与导管内癌的组织病理特征及ER、PR、Her- 2和Ki- 6 7表达的关系进行分析。结果　非肿瘤区、单纯导管内癌、伴有浸润性癌的导管内癌及浸润性癌四组的CD34(+)MVD分别为79.4 5±4 5 .2 3、15 8.39±5 7.2 4、82 .83±37.2 7和10 1.81±4 6 .0 8(个/mm2 ) ,四组间差异有显著意义(P =0 .0 0 0 )。单纯导管内癌CD34(+)MVD较非肿瘤区小叶、伴浸润性癌导管内癌和浸润性癌增加。F8(+)MVD分别为10 8.81±4 9.94、33.4 5±17.79、76 .92±2 5 .14和6 6 .0 1±32 .0 9(个/mm2 ) ,四组间差异有显著性(P =0 .0 0 1)。单纯导管内癌F8(+)MVD较非肿瘤区小叶、伴浸润癌导管内癌和浸润性癌下降。CD34(+)MVD与导管内癌的核分级Ⅲ级、粉刺型及较高的Her- 2和Ki- 6 7的表达相关;但是,F8(+)MVD与导管内癌的核分级、组织类型及Her- 2和Ki - 6 7的表达无关。结论　CD34(+)MVD可以作为预测乳腺导管内癌向浸润癌转化的一项风险指标。Objective To evaluate the ro le of periductal microvessel density (MVD) in predicting the transformation from ductal carcinoma in situ (DCIS) to invasive carcinoma in breast. Met hods The immunohistochemical stain of CD34 and F8 was performed on 6 2 cases of breast cancer (including pure DCIS 12, DCIS with invasive carcinoma 1 3 and invasive carcinoma 37). Computer-aid image processing technique was used t o calculate the MVD. The relationships between periductal MVD and DCIS's histopa thologic features and expressions of ER, PR, Her-2 and Ki-67 were analyzed. Results The CD34(+) MVDs of noncanerous lobule, pure DCIS, DC IS with invasive carcinoma and invasive carcinoma were 79.45± 45.23, 158.39± 57.24, 82.83± 37.27 and 101.81± 46.08(vess els/mm2), respectively. The difference among the four groups was significant (P= 0.000). The CD34(+)MVD of pure DCIS is higher than those of noncancerous lobule, DCIS with invasive carcinoma and invasive carcino m a. The F8(+) MVDs 108.81± 49.94, 33.45± 17.79, 76.92± 25.14 and 66.01± 32.09(vessels/mm2),respectively. The differenc e among the four groups was significant (P= 0.001). Th e F8(+) MVD of pure DCIS is lower than those of noncancerous lobule, DCIS with i n vasive carcinoma and invasive carcinoma. The higher CD34(+)MVD of DCIS was assoc iated with the DCIS with nuclear grade Ⅲ, comedo-type and the higher expression s of Her-2 and Ki-67; the F8(+)MVD of DCIS was not associated with the DCIS with nuclear grade Ⅲ, comedo-type and the expressions of Her-2 and Ki-67. Conclusion The CD34(+) MVD is a risk factor to predict the invasi ve transformation of DCIS.

关 键 词：乳腺导管内癌 MVD CD34 肿瘤 微血管密度 浸润癌 HER-2 转化 表达 显著性 

分 类 号：R737.9[医药卫生—肿瘤] R735[医药卫生—临床医学]