苄基甲苯致癌性和致突变性研究  

The Study on Carcinogenesis and Mutagenesis of Benzyltoluene

作　　者：黄明芳[1] 高青[1] 孟慧林[1] 李忠生[1] 杨惠芳[1] 谢大英[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050

出　　处：《卫生研究》1993年第2期65-67,共3页Journal of Hygiene Research

摘　　要：对苄基甲苯的致癌性和致突变性研究的结果表明:Ames试验、小鼠骨髓多染性红细胞微核试验和小鼠精子畸变试验均为阴性;对小鼠的诱癌试验结果肿瘤发生率实验组虽高于对照组,但经统计学处理(X^2检验)均无显著性差异(P>0.05);肿瘤的潜伏期、肿瘤的特异性和多发性,实验组与对照组相比亦无显著性差异,故初步认为苄基甲苯对小鼠无明显的致癌作用。Benzyltoluene is used in the manufacture of electric condenser as an isolation material. The study on its carcinogenesis and mutagenesis was performed. The Ames test, the micronucleus test of marrow polychroma- tophilic erythrocytes in mice and the sperm malformation test in mice were negative.The neoplasm induction test in mice showed that tumour incidence is higher in the treated groups than in the control groups, but there is not significant difference statistically.No difference had been found in latent time and the multiplicity of tumors between the experimental and control groups.The result indicated that there is no obvious carcinogenetic effect of benzyltoluene on mice.

关 键 词：苄基甲苯 致癌性 致突变性 肿瘤 

分 类 号：R730.231.1[医药卫生—肿瘤]