3-硝基丙酸尾-壳核损伤动物模型的建立和初步应用  

Establishment and application of animal model of caudate-putamen damage induced by 3-nitropropionic acid in rats

作　　者：付以同[1] 焦小云 何凤生[1] 张寿林[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050

出　　处：《卫生研究》1993年第3期137-140,共4页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：首先以3-硝基丙酸(3-NPA)10mg/kg腹腔注射,每日6次,每次间隔1.5h的染毒方式,在大鼠中复制出一个重复性较好的3-NPA尾-壳核损伤的动物模型。然后利用模型染毒方式研究了3-NPA中毒大鼠血脑屏障的改变情况。结果表明血脑屏障破坏属于继发性改变。A reproducible animal model of caudate-putamen damage was estab- lished in rats intraperitonealy dosed with 10mg/kg 3-nitropropionic acid (3-NPA),six times a day with an interval of 1.5 hours for 3~5 days. Using this animal model of caudate-putamen damage, change of blood- brain barrier(BBB)was investigated in rats intoxicated with 3-NPA.The result showed that alteration of BBB may appear but as a secondary event.

关 键 词：3-硝基丙酸 尾-壳核损伤 动物模型 

分 类 号：R595.7[医药卫生—内科学]