卵磷脂抗石英毒作用的研究  

RESEARCH OF RESISTANCE OF LECITHIN TO TOXICITY OF QUARTZ

作　　者：胡继岳[1,2] 谢吉民[1,2] 朱卫华[1,2] 辛淮生[1,2] 

机构地区：[1]镇江医学院,镇江212001 [2]南京大学配位化学国家重点实验室,南京210008

出　　处：《无机化学学报》1993年第2期134-138,共5页Chinese Journal of Inorganic Chemistry

基　　金：南京大学配位化学国家重点实验室;江苏省卫生厅科技发展基金资助项目

摘　　要：本文采用家兔肺泡巨噬细胞(AM)体外培养法,以细胞内游离钙浓度([Ca^(2+)]_i)、细胞存活率、乳酸脱氢酶(LDH)和酸性磷酸酶(ACP)活性为指标,观察了卵磷脂、脑磷脂及现用防治硅肺药物克矽平(PVPNO)、柠檬酸铝等抗石英毒效果。结果表明:卵磷脂在所试各药物中效果最佳.初步探讨了卵磷脂拮抗石英细胞毒性的机理.卵磷脂有成为防治硅肺药物的可能性.Authors studied about the resistance effects of lecithin and some anti-silicosis drugs, such as PVPNO and aluminium citrate, to the toxicity of quartz by means of external culture of alveolar macrophagc of rabbit with the indexes of the cells' survival percent, cytoplasmic free Ca2+ concentration, the activities of LDH and ACP. The results indicate that lecithin is the most effective and it will become probably an ideal drug which prevents and cures silicosis. Besides, the machanism of lecithin's reducing the toxicity of quartz is discussed.

关 键 词：卵磷脂 石英 硅肺 细胞毒性 

分 类 号：R979.3[医药卫生—药品]