儿童青少年双生子胰岛素敏感性的遗传度估计及影响因素分析  

Heritability analysis of insulin sensitivity and the effect of age and sex: a twin study in Chinese aged 5-18

作　　者：陈天娇[1] 季成叶[1] 逄增昌[2] 杨业鹏[3] 王伟[1] 李红娟[1] 胡永华[4] 

机构地区：[1]北京大学儿童青少年卫生研究所,北京100083 [2]山东省青岛市疾病控制中心 [3]北京大学基础医学院放射医学教研室 [4]北京大学公共卫生学院流行病与卫生统计学系

出　　处：《北京大学学报（医学版）》2005年第1期90-93,共4页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金项目 (30 371 2 2 3 ) ;国家重点基础研究发展规划项目基金 (2 0 0 1CB51 0 31 0 )资助~~

摘　　要：目的 :分析影响儿童青少年的胰岛素敏感性的遗传和环境因素 ,并探讨其中体质指数 (bodymassindex ,BMI)、年龄和性别的作用。方法 :选择 5～ 18岁同性别双生子 2 96对 ,平均年龄 (12 4± 3 5 )岁 ,其中同卵双生子(MZ) 2 2 3对 ,异卵双生子 (DZ) 73对。在DNA卵性鉴定基础上 ,应用Mx软件模型拟合分别计算BMI调整前后稳态模型胰岛素抵抗指数 (homeostasismodelassessmentinsulinresistanceindex ,HOMAIR)和 β细胞功能指数 (HOMAβ cellfunctionindex ,HBCI)的遗传度 ,并检验年龄和性别对于模型的作用。结果 :HOMAIR与年龄、性别和BMI相关 ,HBCI与年龄相关 ,遗传分析HOMAIR、HBCI的模型为ACE ,BMI调整前后HOMAIR男女生遗传度不同 ,HB CI无明显变化。调整后HOMAIR、HBCI遗传度分别为 0 .2 5、0 .2 4。结论 :儿童青少年人群中HOMAIR、HBCI受遗传和环境因素共同作用 ,环境因素的影响似乎更大 ;BMI是影响机体胰岛素敏感性的重要因素 ;年龄和性别对遗传度的影响可能不大。Objective: To study the contribution of genes and environment to the variation of insulin sensitivity, and the effect of body mass index (BMI), age and sex. Methods: A total of 296 healthy same-sex twin pairs were studied, including 223 monozygotic (MZ) and 73 dizygotic (DZ) twin pairs aged 5-18(mean age, 12±4 years). Microsatellite polymorphism (STR) was used to diagnose zygosity of twins. Model-fitting method using Mx package was performed to analyze the genetic and environmental variance of homeostasis model assessment insulin resistance index (HOMA IR) and HOMA β cell function index (HBCI), before and after adjusting BMI. The effect of age and sex on the model was tested. Results: HOMA IR was correlated with age, sex and BMI, while HBCI was correlated with age. Genetic analysis showed in ACE model, heritability of HOMA IR in boys and girls was different before and after BMI adjustment; heritability of HBCI was not different significantly. Heritability of HOMA IR and HBCI were 0.25, 0.24, respectively, after adjusting BMI. Conclusion: Gene and environment influence insulin sensitivity of children and adolescents together, whereas environment seems to play a more important role. The effect of BMI on estimating heritability of insulin sensitivity is considerable, differing from sex or age.

关 键 词：胰岛素 人体质量指数 双生研究 儿童 青少年 

分 类 号：R725.87[医药卫生—儿科]