兔肝血管插管技术及兔VX_2肝癌超声、DSA表现的实验研究  

The Experimental Studies on Catheterization of Rabbit Hepatic Artery and the DSA and Ultrasound Features of VX_2 Liver Tumor in Rabbits

作　　者：刘振堂[1] 郭万亮[1] 戴社教[1] 张大鲲[2] 胡洪兵 周斌[1] 毛继刚 史步进 陈凯[1] 程丽丽[1] 张亚红[1] 李迎春[1] 牛风枝 

机构地区：[1]西安交通大学第二医院影像中心,陕西西安710004 [2]西安交通大学第二医院超声室,陕西西安710004 [3]陕西安康中心医院放射科 [4]兰州医学院第一附属医院骨科 [5]陕西蒲城创伤医院放射科

出　　处：《实用放射学杂志》2005年第2期113-116,共4页Journal of Practical Radiology

摘　　要：　　目的　探讨兔肝血管的解剖、插管技术及兔VX2 肝癌的超声、DSA表现的特点。方法　采用经开腹注入法接种VX2 瘤株于 45只新西兰大白兔,于种植后第 7、10、14、18、23天利用彩超对肿瘤的生长进行检测,于接种后第 23天,随机对 10只兔肝癌最大径行超声和病理结果作对照。于种植后第 3周采用Seldinger法穿刺股动脉,并利用 3F微导管与微导丝对兔肝血管插管并造影。结果　彩超检测有 40只成功接种,VX2 肝癌在超声上表现为低回声伴声晕的肿块,彩色多普勒可见肿块周边血供丰富,超声与病理对照结果无统计学差异(Ρ>0. 05)。并对 45只进行血管造影中, 10只超选择至肝固有动脉, 30只插管于肝总动脉, 2只导管置于腹腔干, 3只失败,造影可发现肿瘤血管与肿瘤染色。结论　兔肝血管解剖与人类的相类似,兔VX2 肝癌的DSA、超声表现类似于人类原发性肝癌, 3F微导管可成功地进行肝血管的超选择插管,彩色超声是一种准确、可靠、方便的检测手段。Objective To study the catheterization and the anatomy of rabbit hepatic artery as well as the DSA and ultrasound features of VX 2 liver tumor in rabbits. Methods 45 New Zealand rabbits were injected with VX 2 tumor piece in liver lobe by abdominal incision. Ultrasound technique was applied to detect the liver tumor size after implanted 7th day, 10th day, 14th day, 18th day and 23rd day respectively.10 rabbits were selected at random in comparing the ultrasound imaging of the tumors’ maximum diameter with the results of the pathology. Seldinger’s centesis was adopted to puncture the femoral artery, and 3F micro-catheter was used to catheterize rabbits’ hepatic artery and performed to hepatic arteriography after implantation 3 weeks.Results 40 rabbits were inoculated successfully.The tumors were demonstrated as low echo companied with dark circle which was hypervascular showed by CDFI.There was no difference between ultrasound and pathology in detecting the maximum diameter of tumor(Ρ>0.05).45 rabbits were catheterized hepatic artery.10 cases were introduced to the prop hepatic artery, 30 cases were introduced to common hepatic artery,2 whites rabbits were introduced to celiac trunk and 3 cases failed respectively.Tumor vessel and tumor staining could be found on angiograph.Conclusion The anatomy of hepatic artery , the feature of ultrasound and blood supply of VX 2 liver tumor in rabbits are similar to those of human being.3F catheter can be applied in superselective catheterization of hepatic artery. The ultrasound technique is an accurate, reliable and convenient method in detecting VX 2 liver tumor.

关 键 词：肝血管 肝肿瘤 VX2 介入性放射学 超声 

分 类 号：R-332[医药卫生] R735.7