Bio-oss结合Bio-gide修复牙种植体周围骨缺损的组织学研究  

Histological Studies on the Regeneration of Bone Defect in Dental Implant with Bio-oss and Bio-gide.

作　　者：耿威[1] 宿玉成[1] 徐刚[1] 林润台[1] 

机构地区：[1]中国医学科学院北京协和医院口腔种植中心,北京100032

出　　处：《口腔医学研究》2005年第1期4-7,共4页Journal of Oral Science Research

基　　金：国家十五科技攻关资助项目(编号:2004BA720A27)

摘　　要：目的:通过制作带有种植体的硬组织磨片,评价无机牛骨(deproteinizednaturalbovinemineral,Bio-oss)结 合可吸收性胶原膜(bioresorbablecollagenmambrane,Bio-gide)在牙种植体周围骨缺损中的引导骨再生作用及效 果。方法:在兔股骨植入羟基磷灰石涂层BLB种植体,并在其外侧壁制造标准骨缺损,A组在骨缺损处植入Bio- oss颗粒并在其表面覆盖Bio-gide膜,B组作为空白对照,分别于术后1、2、4、6个月取样品,通过带种植体的硬组 织切片进行骨组织形态学分析。结果:术后1个月Bio-oss颗粒表面有新骨形成,随时间延长Bio-oss发生降解 吸收,新生骨量增加,并与种植体表面形成骨性结合。结论:可吸收性胶原膜Bio-gide结合Bio-oss应用于牙种 植体周围骨缺损中,可以引导骨组织再生,重建缺损的骨组织,新生骨与种植体形成骨性结合。Objective: The aim was to evaluate effectiveness of deproteinized natural bovine mineral(Bio-oss)with bioresorbable collagen mambrane(Bio-gide), for guided bone regeneration in bone defect around implants. Methods: Fixtures coated by HA were implanted. Standard opening bone defect was made on one side of every fixture. Rabbits in group A were implanted with Bio-oss and covered with Bio-gide on surface. The rabbits in group B were negative contrast . In the 1,2,4,and 6 postoperative months, The animals were killed and sampled, then hard-tissue sections with implants were produced for histological analysis. Results: New bone formation occurred along surface of Bio-oss after one month, newly formed bone were increased with time and contacted to the surface of the implants. Conclusion: Bio-oss combining with Bio-gide can guide the bone regeneration and repair bone defect around implant. New bone was contacted to the surface of implants, and osseointegration was formed.

关 键 词：牙种植 引导骨再生 无机牛骨 可吸收性胶原膜 

分 类 号：R783[医药卫生—口腔医学]