E^(838)对小鼠辐射防护作用的研究  

Radiation protective effects of four kind of estrogens on mice

作　　者：王月英[1] 王汝勤[1] 赵忠萍[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津300192

出　　处：《中华放射医学与防护杂志》2005年第1期39-40,共2页Chinese Journal of Radiological Medicine and Protection

基　　金：天津市自然科学重点基金资助项目 (0 43 80 2 411)

摘　　要：目的　本研究对比观察E838、炔雌醇 (EE2 )、炔雌三醇 (EE3)、雌三醇 (E3)对照射小鼠 30d存活率及E838、炔雌醇雌活性对比测定。方法　实验分E838、EE2 、EE3、E3、对照共 5组 ,第 1批小鼠照射前 36h腹腔注射给药 1次 ,对照组腹腔注射茶油 ,第 2批小鼠在照射前 3d连续腹腔注射给药、对照组注射茶油 ,每日 1次 ,经1 37Csγ射线 8 0Gy全身一次性照射后 ,观察小鼠生存天数。出生 18d雌性小鼠腹腔注射 0 2ml,连续 3d给药后取子宫称重。结果　照射前 3d连续注射E838药物效价最高 ,存活率提高 33 9% ,雌活性低。结论　E838药物对造血组织有明显的放射防护作用 ,毒副作用小 ,能提高机体的防御能力。Objective To observe the radioprotective effect of E 838, ethinyl estradiol (EE 2), ethinyl estriol (EE 3), estrio (E 3) on survival rate of KM mice irradiated with 8.0 Gy γ-rays,and compare estrogen activities of E 838 and EE 2. Methods Five groups of KM mice were injected intraperi-toneally with E 838,EE 2,EE 3,E 3 and tea oil (control group) respectively at 36 h or during 3 succesive days before irradiation. The doses were 25 μg for E 838, EE 2, 100 μg for EE 3 and E 3 per mouse.Female mice of 18 days old were injected with E 838 and EE 2 on 3,2 and 1 before irradiation. The radiation dose was 8 Gy 137Cs γ-rays with dose rate 1 Gy/min. Results The 30-day survival rate of mice injected with E 838 on 3,2 and 1 before irradiation was the highest,and the averaged survival rate was 33.9% higher than that of the control group. The estrogen activity of E 838 was low. Conclusion E 838 is an effectively protective drug aganist radiation.\;

关 键 词：小鼠 腹腔注射 照射 给药 辐射防护作用 对照组 炔雌醇 EE 存活率 称重 

分 类 号：R96[医药卫生—药理学]